Journal ArticleDOI
The glial scar and central nervous system repair
TLDR
Deyelinated plaques in multiple sclerosis consists mostly of scar-type astrocytes and naked axons, but astroCytes inhibit the migration of both oligodendrocyte precursors and Schwann cells which must restrict their access to demyelinated axons.About:
This article is published in Brain Research Bulletin.The article was published on 1999-08-01. It has received 1833 citations till now. The article focuses on the topics: Remyelination & Neuroglia.read more
Citations
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Hydrogels in regenerative medicine
Brandon V. Slaughter,Shahana S. Khurshid,Omar Z. Fisher,Ali Khademhosseini,Nicholas A. Peppas +4 more
TL;DR: The properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed.
Journal ArticleDOI
Chondroitinase ABC promotes functional recovery after spinal cord injury
Elizabeth J. Bradbury,Lawrence D. F. Moon,Lawrence D. F. Moon,Reena J Popat,V.R. King,GS Bennett,Preena N. Patel,James W. Fawcett,Stephen B. McMahon +8 more
TL;DR: It is demonstrated that CSPGs are important inhibitory molecules in vivo and suggested that their manipulation will be useful for treatment of human spinal injuries.
Journal ArticleDOI
Response of brain tissue to chronically implanted neural electrodes.
TL;DR: This review presents the biological components and time course of the acute and chronic tissue reaction in brain tissue, analyses the brain tissue response of current electrode systems, and comments on the various material science and bioactive strategies undertaken by electrode designers to enhance electrode performance.
Journal ArticleDOI
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Tommaso Pizzorusso,Paolo Medini,Nicoletta Berardi,Sabrina Chierzi,James W. Fawcett,Lamberto Maffei +5 more
TL;DR: The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.
Book
Müller Cells in the Healthy and Diseased Retina
Andreas Bringmann,Thomas Pannicke,Jens Grosche,Mike Francke,Peter Wiedemann,Serguei N. Skatchkov,Neville N. Osborne,Andreas Reichenbach +7 more
TL;DR: A proper understanding of the gliotic responses of Müller cells in the diseased retina, and of their protective vs. detrimental effects, is essential for the development of efficient therapeutic strategies that use and stimulate the neuron-supportive/protective-and prevent the destructive-mechanisms of gliosis.
References
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Journal ArticleDOI
Microglia: a sensor for pathological events in the CNS
TL;DR: An understanding of intercellular signalling pathways for microglia proliferation and activation could form a rational basis for targeted intervention on glial reactions to injuries in the CNS.
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Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
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Long-distance neuronal migration in the adult mammalian brain
TL;DR: Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
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Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
TL;DR: Evidence is presented that ependymal cells are neural stem cells and a novel process in the response to central nervous system injury is identified, identified in response to spinal cord injury.
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Reactive astrocytes: cellular and molecular cues to biological function
TL;DR: Reactive astrocytes should be considered a key element, like neurons, of a dynamic environment, thus forming with neurons a functional unit involved in homeostasis, plasticity and neurotransmission.