Journal ArticleDOI
The gut microbiome as therapeutic target
Reads0
Chats0
TLDR
Novel findings are discussed that may partly explain how the microbial community participates in the development of the fat mass development, insulin resistance and low-grade inflammation that characterise obesity.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2011-05-01. It has received 318 citations till now. The article focuses on the topics: Dysbiosis & Gut flora.read more
Citations
More filters
Journal ArticleDOI
Microbial degradation of complex carbohydrates in the gut
TL;DR: The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.
Journal ArticleDOI
Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
TL;DR: In this article, the role of the Gut Microbiota in the development of metabolic endotoxemia is discussed, as well as its role in specific dietary treatments (prebiotics and probiotics) and surgical interventions.
Journal ArticleDOI
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease
TL;DR: The role of the microbiota and the potential for diet-induced dysbiosis in inflammatory conditions of the GI tract and systemic diseases will be discussed.
Journal ArticleDOI
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
Ana Paula Boroni Moreira,Tatiana Fiche Salles Texeira,A.B. Ferreira,Maria do Carmo Gouveia Peluzio,Rita de Cássia Gonçalves Alfenas +4 more
TL;DR: The current knowledge about high-fat diets and subclinical inflammation is discussed and the new evidence that correlates gut microbiota, intestinal permeability and alkaline phosphatase activity with increased blood LPS levels and the biological effects of this increase, such as insulin resistance are described.
Journal ArticleDOI
Adaptive immunity in obesity and insulin resistance
TL;DR: The evidence for infiltration of adipose tissue by cells of the adaptive immune system, how adaptive system cells affect innate cell populations and the influence of adaptive immune cells on the development of insulin resistance are summarized.
References
More filters
Journal ArticleDOI
Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors.
V. Di Marzo,Mélanie Côté,I. Matias,Isabelle Lemieux,Benoit J. Arsenault,Amélie Cartier,Fabiana Piscitelli,Stefania Petrosino,Natalie Alméras,Jean-Pierre Després +9 more
TL;DR: This study shows that a strong correlation exists between 2-AG levels and high plasma triacylglycerol and low HDL3-cholesterol in viscerally obese men.
Journal ArticleDOI
Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects.
TL;DR: It is concluded that wheat fibre increased SCFA production and GLP-1 secretion in hyperinsulinaemic humans, but these effects took 9–12 months to develop.
Journal ArticleDOI
Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators.
TL;DR: Insulin-like growth factor I has been demonstrated to be required for GLP-2-induced crypt cell proliferation, likely involving activation of beta-catenin signaling, and vasoactive intestinal polypeptide modulates the actions of GLp-2 in models of intestinal inflammation, while keratinocyte growth factor is required forGLP- 2-induced colonic mucosal growth and mucin expression.
Journal ArticleDOI
A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans
TL;DR: Both inulin doses exhibited a bifidogenic effect but a higher volunteer percentage responded to the high dose, suggesting that the magnitude of increase in b ifidobacteria levels depended on their initial numbers.
Journal ArticleDOI
Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes.
Mauro Maccarrone,L. De Petrocellis,Monica Bari,Filomena Fezza,S Salvati,V. Di Marzo,Alessandro Finazzi-Agrò +6 more
TL;DR: It is demonstrated that LPS enhances the levels of AEA also in human lymphocytes, and it is shown that in these cells LPS inhibits the activity of the AEA-degrading enzyme fatty acid amide hydrolase (FAAH), by downregulating the gene expression at transcriptional level.
Related Papers (5)
Microbial ecology: Human gut microbes associated with obesity
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more