The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
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TLDR
A portrait of the HECT E3s is provided, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy, to link the substrate specificity of HECT-type E 3s with their contribution to tumorigenesis.About:
This article is published in Cancer Cell.The article was published on 2008-07-08 and is currently open access. It has received 488 citations till now. The article focuses on the topics: Nedd4 Ubiquitin Protein Ligases & Ubiquitin ligase.read more
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Noncoding RNA:RNA Regulatory Networks in Cancer.
Jia Jia Chan,Yvonne Tay +1 more
TL;DR: Recent integrative analyses have provided evidence that new computational platforms and experimental approaches can be harnessed together to distinguish key ceRNA interactions in specific cancers, which could facilitate the identification of robust biomarkers and therapeutic targets, and hence, more effective cancer therapies and better patient outcome and survival.
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Ubiquitination in disease pathogenesis and treatment
TL;DR: The role of ubiquitination in the onset and progression of cancer, metabolic syndromes, neurodegenerative diseases, autoimmunity, inflammatory disorders, infection and muscle dystrophies is described and how current knowledge could be exploited for the development of new clinical therapies is indicated.
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The N-end rule pathway and regulation by proteolysis
TL;DR: Regulated degradation of specific proteins by the N‐end rule pathway mediates a legion of physiological functions, including the sensing of heme, oxygen, and nitric oxide; selective elimination of misfolded proteins; the regulation of DNA repair, segregation, and condensation; the signaling by G proteins; and theregulation of peptide import, fat metabolism, viral and bacterial infections.
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Targeting the ubiquitin system in cancer therapy
TL;DR: Alterations in the ubiquitin system that occur during the initiation and progression of cancer are now being uncovered, and this knowledge is starting to be exploited for both molecular diagnostics and the development of novel strategies to combat cancer.
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The role of ubiquitin in NF-kappaB regulatory pathways.
TL;DR: Recent advances in the identification and characterization of ubiquitination and deubiquitination machinery that regulate NF-kappaB are discussed, specifically its role in the activation of protein kinase complexes and in coordination of cell survival and apoptosis signals downstream of tumor necrosis factoralpha.
References
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The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
TL;DR: It is demonstrated that the E6 proteins of the oncogenic HPVs that bind p53 stimulate the degradation of p53, which results in selective degradation of cellular proteins such as p53 with negative regulatory functions provides a novel mechanism of action for dominant-acting oncoproteins.
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Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Sanford D. Markowitz,Jing Wang,Lois Myeroff,Ramon Parsons,Lu Zhe Sun,James Lutterbaugh,Robert S. Fan,Elizabeth Zborowska,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein,Michael G. Brattain,James K V Willson +12 more
TL;DR: Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene, which links DNA repair defects with a specific pathway of tumor progression.
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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
TL;DR: The purification and identification of TRIKA2, which is composed of TAK1, TAB1 and TAB2, a protein kinase complex previously implicated in IKK activation through an unknown mechanism, indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK.
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Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
Li Deng,Chen Wang,Erika Spencer,Liyong Yang,Amy Braun,Jianxin You,Clive A. Slaughter,Cecile M. Pickart,Zhijian J. Chen +8 more
TL;DR: It is found that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin.