Open Access
The Hippo pathway: an emerging role in urologic cancers.
Bekir Cinar,Esma Alp,Marwah M. Al-Mathkour,Ava M. Boston,Abdulrahman Dwead,Kezhan Khazaw,Alexis Gregory +6 more
- Vol. 9, Iss: 4, pp 301-317
TLDR
The Hippo pathway core kinases MST1/2 and LATS 1/2 in mammals phosphorylate and inactivate YAP1 signaling to prevent cancer growth.Abstract:
The Hippo pathway controls several biological processes, including cell growth, differentiation, motility, stemness, cell contact, immune cell maturation, organ size, and tumorigenesis. The Hippo pathway core kinases MST1/2 and LATS1/2 in mammals phosphorylate and inactivate YAP1 signaling. Increasing evidence indicates that loss of MST1/2 and LATS1/2 function is linked to the biology of many cancer types with poorer outcomes, likely due to the activation of oncogenic YAP1/TEAD signaling. Therefore, there is a renewed interest in blocking the YAP1/TEAD functions to prevent cancer growth. This review introduces the Hippo pathway components and examines their role and therapeutic potentials in prostate, kidney, and bladder cancer.read more
Citations
More filters
Journal ArticleDOI
The Hippo pathway and its correlation with acute kidney injury
TL;DR: This review aims to summarize recent findings on the associations between the Hippo pathway and AKI and to identify new therapeutic targets and strategies for AKI.
Journal ArticleDOI
Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinoma
Deepika Dhawan,José A. Ramos-Vara,Sagar M. Utturkar,Audrey Ruple,Sarah A. Tersey,Jennifer Nelson,Bruce A. Cooper,Hock Gan Heng,Elaine A. Ostrander,Heidi G. Parker,Noah M. Hahn,L. Garry Adams,Christopher M. Fulkerson,Michael O. Childress,Patty L. Bonney,Christine Royce,Lindsey M. Fourez,Alexander W. Enstrom,Lisbeth A. Ambrosius,Deborah W. Knapp +19 more
TL;DR: In this paper , an early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening, and the results showed that the early intervention showed promising results.
Journal ArticleDOI
The Hippo effector YAP1/TEAD1 regulates EPHA3 expression to control cell contact and motility
TL;DR: In this paper , the authors investigated the mechanism by which MST1 regulates EPHA3 and revealed that the transcriptional regulators YAP1 and TEAD1 are crucial activators of EPHA-3 transcription.
Journal ArticleDOI
Integrated molecular analyses of an interferon-γ based subtype with regard to outcome, immune characteristics, and immunotherapy in bladder cancer and experimental verification
TL;DR: In this paper , the role of interferon-γ related genes (IRGs) in the prognosis and immunotherapy of bladder cancer (BC) was explored through Cox regression analyses.
References
More filters
Journal ArticleDOI
Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes.
TL;DR: A cell-permeable kinase probe (DA-2) capable of proteome-wide profiling of potential cellular targets of Dasatinib is successfully developed and should be amenable to the study of many of the existing reversible drugs/drug candidates.
Journal ArticleDOI
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer
Mark P. Labrecque,Ilsa Coleman,Lisha G. Brown,Lawrence D. True,Lori Kollath,Bryce Lakely,Holly M. Nguyen,Yu C. Yang,Rui Costa,Arja Kaipainen,Roger Coleman,Celestia S. Higano,Evan Y. Yu,Evan Y. Yu,Heather H. Cheng,Heather H. Cheng,Elahe A. Mostaghel,Elahe A. Mostaghel,Bruce Montgomery,Bruce Montgomery,Michael T. Schweizer,Michael T. Schweizer,Andrew C. Hsieh,Andrew C. Hsieh,Daniel W. Lin,Daniel W. Lin,Eva Corey,Peter S. Nelson,Peter S. Nelson,Colm Morrissey +29 more
TL;DR: Deep phenotypic characterization of CRPC metastases and patient-derived xenograft lines using whole genome RNA sequencing, gene set enrichment analysis and immunohistochemistry revealed five mCRPC phenotypes based on the expression of well-characterized androgen receptor (AR) or neuroendocrine (NE) genes, highlighting the central role of AR and REST in classifying treatment-resistant mCR PC phenotypes.
Journal ArticleDOI
LATS tumor suppressor: a new governor of cellular homeostasis.
Stacy Visser,Xiaolong Yang +1 more
TL;DR: This review aims to identify what the authors know about the LATS tumor suppressor family, highlighting LATS1 and LATS2 redundancies or differences in terms of their structure, expression, regulation, and functions, thereby establishing a novel tumor suppressionor network.
Journal ArticleDOI
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma
Joana Heinzelmann,Brenda Henning,Jimsgene Sanjmyatav,Nicole Posorski,Thomas Steiner,Heiko Wunderlich,Mieczyslaw Gajda,Kerstin Junker +7 more
TL;DR: It seems possible to use miRNAs for prediction of progression to distant metastasis and prognosis analysing the primary tumour, and correlations between expression levels of specific mi RNAs with progression-free survival and overall survival are found.
Journal ArticleDOI
Metastatic non–clear cell renal cell carcinoma treated with targeted therapy agents: Characterization of survival outcome and application of the International mRCC Database Consortium criteria
Nils Kroeger,Wanling Xie,Jae Lyn Lee,Georg A. Bjarnason,Jennifer J. Knox,Mary J. MacKenzie,Lori Wood,Sandy Srinivas,Ulka N. Vaishamayan,Sun Young Rha,Sumanta K. Pal,Takeshi Yuasa,Frede Donskov,Neeraj Agarwal,Christian Kollmannsberger,Min-Han Tan,Scott North,Brian I. Rini,Toni K. Choueiri,Daniel Y.C. Heng +19 more
TL;DR: This study aimed to apply the International mRCC Database Consortium prognostic model in metastatic non–clear cell renal cell carcinoma (nccRCC) and the survival outcome of metastatic nCCRCC patients was characterized.