Open Access
The Hippo pathway: an emerging role in urologic cancers.
Bekir Cinar,Esma Alp,Marwah M. Al-Mathkour,Ava M. Boston,Abdulrahman Dwead,Kezhan Khazaw,Alexis Gregory +6 more
- Vol. 9, Iss: 4, pp 301-317
TLDR
The Hippo pathway core kinases MST1/2 and LATS 1/2 in mammals phosphorylate and inactivate YAP1 signaling to prevent cancer growth.Abstract:
The Hippo pathway controls several biological processes, including cell growth, differentiation, motility, stemness, cell contact, immune cell maturation, organ size, and tumorigenesis. The Hippo pathway core kinases MST1/2 and LATS1/2 in mammals phosphorylate and inactivate YAP1 signaling. Increasing evidence indicates that loss of MST1/2 and LATS1/2 function is linked to the biology of many cancer types with poorer outcomes, likely due to the activation of oncogenic YAP1/TEAD signaling. Therefore, there is a renewed interest in blocking the YAP1/TEAD functions to prevent cancer growth. This review introduces the Hippo pathway components and examines their role and therapeutic potentials in prostate, kidney, and bladder cancer.read more
Citations
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The Hippo pathway and its correlation with acute kidney injury
TL;DR: This review aims to summarize recent findings on the associations between the Hippo pathway and AKI and to identify new therapeutic targets and strategies for AKI.
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Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinoma
Deepika Dhawan,José A. Ramos-Vara,Sagar M. Utturkar,Audrey Ruple,Sarah A. Tersey,Jennifer Nelson,Bruce A. Cooper,Hock Gan Heng,Elaine A. Ostrander,Heidi G. Parker,Noah M. Hahn,L. Garry Adams,Christopher M. Fulkerson,Michael O. Childress,Patty L. Bonney,Christine Royce,Lindsey M. Fourez,Alexander W. Enstrom,Lisbeth A. Ambrosius,Deborah W. Knapp +19 more
TL;DR: In this paper , an early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening, and the results showed that the early intervention showed promising results.
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The Hippo effector YAP1/TEAD1 regulates EPHA3 expression to control cell contact and motility
TL;DR: In this paper , the authors investigated the mechanism by which MST1 regulates EPHA3 and revealed that the transcriptional regulators YAP1 and TEAD1 are crucial activators of EPHA-3 transcription.
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Integrated molecular analyses of an interferon-γ based subtype with regard to outcome, immune characteristics, and immunotherapy in bladder cancer and experimental verification
TL;DR: In this paper , the role of interferon-γ related genes (IRGs) in the prognosis and immunotherapy of bladder cancer (BC) was explored through Cox regression analyses.
References
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David B. Sacks,Blaise Baxter,Bruce C.V. Campbell,Jeffrey S Carpenter,Christophe Cognard,Diederik W.J. Dippel,Muneer Eesa,Urs Fischer,Klaus A. Hausegger,Joshua A Hirsch,Muhammad S Hussain,Olav Jansen,Mahesh V Jayaraman,Alexander A. Khalessi,Bryan Kluck,S. D. Lavine,Philip M. Meyers,Stephen R. Ramee,Daniel A. Rüfenacht,Clemens M. Schirmer,Dierk Vorwerk +20 more
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Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.
Hans R. Widlund,David E. Fisher +1 more
TL;DR: The transcriptional networks in which MITF is thought to reside are discussed and signaling pathways in the cell which impinge on MITF are described, suggesting that the notion thatMITF is involved in survival pathways during normal development as well as during neoplastic growth of melanoma is supported.
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The Uroepithelium: Not Just a Passive Barrier
TL;DR: New analysis of the uroepithelium is providing information about how detergent‐insoluble membrane/protein domains called plaques are formed at the apical plasma membrane of the surface umbrella cells, how mechanical stimuli such as pressure alter exocytic and endocytic traffic in epithelial cells such as umbrella Cells, and how changes in pressure are communicated to the underlying nervous system.
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Structural insights into the YAP and TEAD complex
Ze Li,Bin Zhao,Ping Wang,Fei Xavier Chen,Zhenghong Dong,Huirong Yang,Kun-Liang Guan,Yanhui Xu +7 more
TL;DR: The three-dimensional structure of the YAP-TEAD1 complex is reported, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces.
Journal ArticleDOI
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation
Fa-Xing Yu,Yifan Zhang,Hyun Woo Park,Jenna L. Jewell,Qian Chen,Yaoting Deng,Duojia Pan,Susan S. Taylor,Zhi Chun Lai,Kun-Liang Guan +9 more
TL;DR: It is demonstrated that cyclic adenosine monophosphate (cAMP), a second messenger downstream from Gαs-coupled receptors, acts through protein kinase A (PKA) and Rho GTPases to stimulate Lats kinases and YAP phosphorylation and reveals new insight into mechanisms of PKA in regulating a broad range of cellular functions.