Open Access
The Hippo pathway: an emerging role in urologic cancers.
Bekir Cinar,Esma Alp,Marwah M. Al-Mathkour,Ava M. Boston,Abdulrahman Dwead,Kezhan Khazaw,Alexis Gregory +6 more
- Vol. 9, Iss: 4, pp 301-317
TLDR
The Hippo pathway core kinases MST1/2 and LATS 1/2 in mammals phosphorylate and inactivate YAP1 signaling to prevent cancer growth.Abstract:
The Hippo pathway controls several biological processes, including cell growth, differentiation, motility, stemness, cell contact, immune cell maturation, organ size, and tumorigenesis. The Hippo pathway core kinases MST1/2 and LATS1/2 in mammals phosphorylate and inactivate YAP1 signaling. Increasing evidence indicates that loss of MST1/2 and LATS1/2 function is linked to the biology of many cancer types with poorer outcomes, likely due to the activation of oncogenic YAP1/TEAD signaling. Therefore, there is a renewed interest in blocking the YAP1/TEAD functions to prevent cancer growth. This review introduces the Hippo pathway components and examines their role and therapeutic potentials in prostate, kidney, and bladder cancer.read more
Citations
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The Hippo pathway and its correlation with acute kidney injury
TL;DR: This review aims to summarize recent findings on the associations between the Hippo pathway and AKI and to identify new therapeutic targets and strategies for AKI.
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Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinoma
Deepika Dhawan,José A. Ramos-Vara,Sagar M. Utturkar,Audrey Ruple,Sarah A. Tersey,Jennifer Nelson,Bruce A. Cooper,Hock Gan Heng,Elaine A. Ostrander,Heidi G. Parker,Noah M. Hahn,L. Garry Adams,Christopher M. Fulkerson,Michael O. Childress,Patty L. Bonney,Christine Royce,Lindsey M. Fourez,Alexander W. Enstrom,Lisbeth A. Ambrosius,Deborah W. Knapp +19 more
TL;DR: In this paper , an early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening, and the results showed that the early intervention showed promising results.
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The Hippo effector YAP1/TEAD1 regulates EPHA3 expression to control cell contact and motility
TL;DR: In this paper , the authors investigated the mechanism by which MST1 regulates EPHA3 and revealed that the transcriptional regulators YAP1 and TEAD1 are crucial activators of EPHA-3 transcription.
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Integrated molecular analyses of an interferon-γ based subtype with regard to outcome, immune characteristics, and immunotherapy in bladder cancer and experimental verification
TL;DR: In this paper , the role of interferon-γ related genes (IRGs) in the prognosis and immunotherapy of bladder cancer (BC) was explored through Cox regression analyses.
References
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Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.
Arjun Vasant Balar,Matthew D. Galsky,Jonathan E. Rosenberg,Thomas Powles,Daniel P. Petrylak,Joaquim Bellmunt,Yohann Loriot,Andrea Necchi,Jean H. Hoffman-Censits,Jose Luis Perez-Gracia,Nancy A. Dawson,Michiel S. van der Heijden,Robert Dreicer,Sandy Srinivas,Margitta Retz,Richard W. Joseph,Alexandra Drakaki,Ulka N. Vaishampayan,Srikala S. Sridhar,David I. Quinn,Ignacio Duran,David R. Shaffer,Bernhard J. Eigl,Petros Grivas,Evan Y. Yu,S. Li,Edward E. Kadel,Zachary Boyd,Richard Bourgon,Priti S. Hegde,Sanjeev Mariathasan,Ann Christine Thastrom,Oyewale O. Abidoye,Gregg Fine,Dean F. Bajorin +34 more
TL;DR: Atezolizumab showed encouraging durable response rates, survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cancer.
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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
TL;DR: The Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status.
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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
TL;DR: The results suggest that the interactions of 14-3-3 with signaling proteins are critical for the activation of signaling proteins and suggest novel roles for serine/threonine phosphorylation in the assembly of protein-protein complexes.
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Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Fa-Xing Yu,Bin Zhao,Nattapon Panupinthu,Jenna L. Jewell,Ian Lian,Lloyd H. Wang,Jiagang Zhao,Hai-Xin Yuan,Karen Tumaneng,Hairi Li,Xiang-Dong Fu,Gordon B. Mills,Kun-Liang Guan +12 more
TL;DR: This study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the hippo-YAP pathway as a critical signaling branch downstream of GPCR.
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YAP/TAZ at the Roots of Cancer
TL;DR: In this paper, a number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling, and regulation of the Hippo pathway.