The Impact of Fusarium Mycotoxins on Human and Animal Host Susceptibility to Infectious Diseases
Gunther Antonissen,An Martel,Frank Pasmans,Richard Ducatelle,Elin Verbrugghe,Virginie Vandenbroucke,Shaoji Li,Freddy Haesebrouck,Filip Van Immerseel,Siska Croubels +9 more
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TLDR
This review summarizes the current state of knowledge about the impact of Fusarium mycotoxin exposure on human and animal host susceptibility to infectious diseases and indicates possible exacerbation of colibacillosis and salmonellosis in humans, as well.Abstract:
Contamination of food and feed with mycotoxins is a worldwide problem. At present, acute mycotoxicosis caused by high doses is rare in humans and animals. Ingestion of low to moderate amounts of Fusarium mycotoxins is common and generally does not result in obvious intoxication. However, these low amounts may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host pathogen interactions and thus a different outcome of infection. This review summarizes the current state of knowledge about the impact of Fusarium mycotoxin exposure on human and animal host susceptibility to infectious diseases. On the one hand, exposure to deoxynivalenol and other Fusarium mycotoxins generally exacerbates infections with parasites, bacteria and viruses across a wide range of animal host species. Well-known examples include coccidiosis in poultry, salmonellosis in pigs and mice, colibacillosis in pigs, necrotic enteritis in poultry, enteric septicemia of catfish, swine respiratory disease, aspergillosis in poultry and rabbits, reovirus infection in mice and Porcine Reproductive and Respiratory Syndrome Virus infection in pigs. However, on the other hand, T-2 toxin has been shown to markedly decrease the colonization capacity of Salmonella in the pig intestine. Although the impact of the exposure of humans to Fusarium toxins on infectious diseases is less well known, extrapolation from animal models suggests possible exacerbation of, for instance, colibacillosis and salmonellosis in humans, as well.read more
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TEER Measurement Techniques for In Vitro Barrier Model Systems
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Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed
Helle Katrine Knutsen,Jan Alexander,Lars Barregård,Margherita Bignami,Beat Johannes Brüschweiler,Sandra Ceccatelli,Bruce Cottrill,Michael Dinovi,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Carlo Nebbia,Isabelle P Oswald,Annette Petersen,Martin Rose,Alain-Claude Roudot,Tanja Schwerdtle,Christiane Vleminckx,Günter Vollmer,Heather M. Wallace,Sarah De Saeger,Gunnar Sundstøl Eriksen,Peter B. Farmer,Jean-Marc Fremy,Yun Yun Gong,Karsten Meyer,Hanspeter Naegeli,Dominique Parent-Massin,Ivonne M.C.M. Rietjens,Hans P. van Egmond,Andrea Altieri,Mari Eskola,Petra Gergelova,Luisa Ramos Bordajandi,Bistra Benkova,Barbara Dörr,Athanasios Gkrillas,Nicklas Gustavsson,Mathijs van Manen,Lutz Edler +39 more
TL;DR: The estimated mean chronic dietary exposure was above the group‐TDI in infants, toddlers and other children, and at high exposure also in adolescents and adults, indicating a potential health concern.
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In vivo toxicity studies of fusarium mycotoxins in the last decade: a review.
TL;DR: In vivo research on Fusarium mycotoxins has increased since 2010 highlighting the need for such studies in the field of food and feed safety and the most common studies are classified as subacute toxicity, subchronic toxicity, acute toxicity, toxicokinetic studies and teratogenicity.
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Review on Mycotoxin Issues in Ruminants: Occurrence in Forages, Effects of Mycotoxin Ingestion on Health Status and Animal Performance and Practical Strategies to Counteract Their Negative Effects
Antonio Gallo,Gianluca Giuberti,Jens Christian Frisvad,Terenzio Bertuzzi,Kristian Fog Nielsen +4 more
TL;DR: This review includes the knowledge of mycotoxin occurrence reported in the last 15 years, with special emphasis on mycotoxins detected in forages, and animal toxicological issues due to their ingestion.
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Prevalence and effects of mycotoxins on poultry health and performance, and recent development in mycotoxin counteracting strategies
G. R. Murugesan,David R. Ledoux,Karin Naehrer,Franz Berthiller,Todd J. Applegate,Bertrand Grenier,Timothy D. Phillips,Gerd Schatzmayr +7 more
TL;DR: This symposium review paper comprehensively discusses the awareness on the prevalence of mycotoxins, available modern techniques to analyze them, the effects ofMycotoxicoses, and the recent developments in the ways to safely eliminate the mycotoxin from the feed.
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