Open AccessJournal Article
The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009
TLDR
A comprehensive review of the studies performed on cognitively healthy individuals, from the first study conducted in 1995 to present, can be found in this paper, where the strong and weak methodologies for future study design are identified and suggestions for future design will be presented.About:
This article is published in Journal of Psychiatric Research.The article was published on 2009-01-01 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Cognitive skill & Cognitive deficit.read more
Citations
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Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
Cornelius A. Rietveld,Tõnu Esko,Gail Davies,Tune H. Pers,Patrick Turley,Beben Benyamin,Christopher F. Chabris,Valur Emilsson,Andrew D. Johnson,James J. Lee,C. deLeeuw,Riccardo E. Marioni,Sarah E. Medland,Michael B. Miller,Olga Rostapshova,S.J. van deLee,Anna A. E. Vinkhuyzen,Najaf Amin,Dalton Conley,Jaime Derringer,C.M. vanDuijn,Rudolf S N Fehrmann,Lude Franke,E.L. Glaeser,Narelle K. Hansell,Caroline Hayward,William G. Iacono,Carla A. Ibrahim-Verbaas,Vincent W. V. Jaddoe,Juha Karjalainen,David Laibson,Paul Lichtenstein,D C Liewald,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Gearoid M. McMahon,Nancy L. Pedersen,Steven Pinker,David J. Porteous,Danielle Posthuma,F. Rivadeneira Ramirez,B.H. Smithk,John M. Starr,Henning Tiemeier,N.J. Timpsonm,M. Trzaskowskin,A.G. Uitterlinden,Frank C. Verhulst,Mary E. Ward,Margaret J. Wright,Albert V. Smith,Ian J. Deary,Magnus Johannesson,Robert Plomin,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,Koellinger +58 more
TL;DR: This work identifies several common genetic variants associated with cognitive performance using a two-stage approach: a genome-wide association study of educational attainment to generate a set of candidates, and then the association of these variants with Cognitive performance is estimated.
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
G. Davies,Nicola J. Armstrong,J. C. Bis,Jan Bressler,Vincent Chouraki,Sudheer Giddaluru,Edith Hofer,Carla A. Ibrahim-Verbaas,Mirna Kirin,Jari Lahti,S. J. van der Lee,S. Le Hellard,Tian Liu,Riccardo E. Marioni,Christopher Oldmeadow,Iris Postmus,Albert V. Smith,Jacqueline Smith,Anbupalam Thalamuthu,Russell Thomson,Veronique Vitart,Jie Jin Wang,Le Yu,Lina Zgaga,Wei Zhao,Ruth Boxall,Sarah E. Harris,WD Hill,D C Liewald,Michelle Luciano,Hieab H.H. Adams,David Ames,Najaf Amin,P. Amouyel,Amelia A. Assareh,Rhoda Au,James T. Becker,Alexa S. Beiser,Claudine Berr,Lars Bertram,Eric Boerwinkle,Brendan M. Buckley,Harry Campbell,Janie Corley,P. L. De Jager,Carole Dufouil,Johan G. Eriksson,Thomas Espeseth,Jessica D. Faul,Ian Ford,Rebecca F. Gottesman,Michael Griswold,Vilmundur Gudnason,T.B. Harris,Gerardo Heiss,Albert Hofman,Elizabeth G. Holliday,Jennifer E. Huffman,Sharon L.R. Kardia,Nicole A. Kochan,D. S. Knopman,John B.J. Kwok,J-C Lambert,Teresa Lee,Ge Li,S-C Li,Marisa Loitfelder,Oscar L. Lopez,Astri J. Lundervold,Annamari Lundqvist,Karen A. Mather,Saira Saeed Mirza,Lars Nyberg,B.A. Oostra,A. Palotie,Goran Papenberg,Alison Pattie,K. Petrovic,Ozren Polasek,Bruce M. Psaty,Paul Redmond,Simone Reppermund,Jerome I. Rotter,H. Schmidt,Maaike Schuur,Peter Schofield,Rodney J. Scott,Vidar M. Steen,David J. Stott,J. C. van Swieten,K. D. Taylor,Julian N. Trollor,Stella Trompet,André G. Uitterlinden,Galit Weinstein,Elisabeth Widen,Beverly Gwen Windham,Joop Jukema,A. F. Wright,Margaret J. Wright,Qiong Yang,Hélène Amieva,John Attia,David A. Bennett,Henry Brodaty,A.J.M. de Craen,Caroline Hayward,M. A. Ikram,Ulman Lindenberger,L-G Nilsson,David J. Porteous,Katri Räikkönen,Ivar Reinvang,Igor Rudan,Perminder S. Sachdev,R. Schmidt,Peter R. Schofield,Velandai Srikanth,John M. Starr,Stephen T. Turner,David R. Weir,James F. Wilson,C M van Duijn,L. J. Launer,Annette L. Fitzpatrick,Sudha Seshadri,Thomas H. Mosley,Ian J. Deary +127 more
TL;DR: This paper conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests and created a general cognitive function phenotype, and created in each cohort by principal component analysis.
DissertationDOI
Predicting Cognitive Decline: Genetic, Environmental and Lifestyle Risk Factors
TL;DR: In this paper, the authors propose a method to solve the problem of "uniformity" and "uncertainty" in the context of data mining, and propose a solution.
Dissertation
Lifestyle factors and cognitive ageing in the Lothian Birth Cohort 1936: exploring the role of confounding by prior cognitive ability
TL;DR: The positive and significant associations observed between ‘healthy’ lifestyle factors and better cognitive functions at age 70 were consistent with previous research; their effect size was around 1% of the variance in cognitive tests scores.
Journal Article
SNPs, microarrays, and pooled DNA: Identification of four loci associated with mild mental impairment in a sample of 6000 children
Lee M. Butcher,Emma L. Meaburn,Jo Knight,Pak C. Sham,Leonard C. Schalkwyk,Ian W. Craig,Robert Plomin +6 more
TL;DR: Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses.
References
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A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
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Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
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The processing-speed theory of adult age differences in cognition.
TL;DR: A theory is proposed that increased age in adulthood is associated with a decrease in the speed with which many processing operations can be executed and that this reduction in speed leads to impairments in cognitive functioning because of what are termed the limited time mechanism and the simultaneity mechanism.