J
Joop Jukema
Researcher at Leiden University Medical Center
Publications - 191
Citations - 14570
Joop Jukema is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Population & Coronary artery disease. The author has an hindex of 40, co-authored 190 publications receiving 12667 citations.
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Journal ArticleDOI
The interplay between habitat availability and population differentiation
Yvonne I. Verkuil,Theunis Piersma,Joop Jukema,Leo Zwarts,Allan J. Baker,Jos C.E.W. Hooijmeijer +5 more
Journal ArticleDOI
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Paolo Zanoni,Sumeet A. Khetarpal,Daniel B. Larach,Hancock-Cerutti Wf,John S. Millar,Marina Cuchel,Stephanie DerOhannessian,Anatol Kontush,Praveen Surendran,Danish Saleheen,Stella Trompet,Joop Jukema,De Craen A,Panos Deloukas,Naveed Sattar,Ian Ford,Chris J. Packard,Majumder Aa,Dewan S. Alam,Di Angelantonio E,Gonçalo R. Abecasis,Rajiv Chowdhury,Jeanette Erdmann,Børge G. Nordestgaard,Sune F. Nielsen,Anne Tybjærg-Hansen,Schmidt Rf,Kari Kuulasmaa,Dajiang J. Liu,Markus Perola,Stefan Blankenberg,Salomaa,Satu Männistö,P. Amouyel,Dominique Arveiler,Jean Ferrières,Martina Müller-Nurasyid,Marco M Ferrario,Frank Kee,Cristen J. Willer,Nilesh J. Samani,Heribert Schunkert,Adam S. Butterworth,Joanna M. M. Howson,Gina M. Peloso,Nathan O. Stitziel,John Danesh,Sekar Kathiresan,Daniel J. Rader +48 more
TL;DR: In this paper, the authors identified a homozygote for a loss-of-function variant, in which leucine replaces proline 376 (P376L), in SCARB1, the gene encoding SR-BI.
Journal ArticleDOI
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah,Albert Henry,Carolina Roselli,Honghuang Lin,G Sveinbjörnsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Morley Mp,Mark Chaffin,Anna Helgadottir,Niek Verweij,Niek Verweij,Abbas Dehghan,Peter Almgren,C. Andersson,Krishna G. Aragam,Krishna G. Aragam,Johan Ärnlöv,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeff Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Dörr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,T Esko,T Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daníel F. Guðbjartsson,Daníel F. Guðbjartsson,Rebecca Gutmann,Christopher M. Haggerty,P. van der Harst,Craig L. Hyde,Erik Ingelsson,Joop Jukema,Maryam Kavousi,Khaw K-T.,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrick K.E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,März W,März W,März W,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Thomas M. Morgan,Andrew D. Morris,Andrew P. Morris,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Palmer Cna.,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Romaine Spr.,Jerome I. Rotter,Perttu Salo,Veikko Salomaa,J. van Setten,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Steen Stender,David J. Stott,Per Svensson,Tammesoo M-L.,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Guðmundur Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,André G. Uitterlinden,André G. Uitterlinden,Abirami Veluchamy,Uwe Völker,Adriaan A. Voors,Xianyuan Wang,Nicholas J. Wareham,Dawn M. Waterworth,P.E Weeke,Raul Weiss,Kerri L. Wiggins,Huilin Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Nilesh J. Samani,McMurray Jjv.,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Christopher Newton-Cheh,Anders Mälarstig,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Michael V. Holmes,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,Kari Stefansson,J. G. Smith,J. G. Smith,Ramachandran S. Vasan,Daniel I. Swerdlow,R. T. Lumbers +167 more
TL;DR: Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension.
Journal ArticleDOI
Cholesteryl Ester Transfer Protein TaqIB Variant, High-Density Lipoprotein Cholesterol Levels, Cardiovascular Risk, and Efficacy of Pravastatin Treatment Individual Patient Meta-Analysis of 13 677 Subjects
S.M. Boekholdt,Frank M. Sacks,Joop Jukema,J. Shepherd,Dilys J. Freeman,Alex D. McMahon,François Cambien,Viviane Nicaud,G.J. de Grooth,P.J. Talmud,S.E. Humphries,George J. Miller,G. Eiriksdottir,Vilmundur Gudnason,Heikki Kauma,Sakari Kakko,Markku J. Savolainen,Marcello Arca,A. Montali,Simin Liu,H.J. Lanz,A. H. Zwinderman,J. A. Kuivenhoven,John J. P. Kastelein +23 more
TL;DR: The CETP TaqIB variant is firmly associated with HDL-C plasma levels and as a result, with the risk of CAD, and does not influence the response to pravastatin therapy.
Journal ArticleDOI
Common Genetic Variation in ABCA1 Is Associated With Altered Lipoprotein Levels and a Modified Risk for Coronary Artery Disease
Susanne M. Clee,A. H. Zwinderman,James C. Engert,K.Y. Zwarts,H.O. Molhuizen,Kirsten Roomp,Joop Jukema,M van Wijland,M. Van Dam,Thomas J. Hudson,Angela Brooks-Wilson,Jacques Genest,J.J.P. Kastelein,Michael R. Hayden +13 more
TL;DR: Common variation in ABCA1 significantly influences plasma lipid levels and the severity of CAD, and Atherosclerosis progresses more slowly in carriers of R219K than in noncarriers.