The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
TLDR
The endocannabinoid system has important physiological functions not only in the central nervous system but also in peripheral tissues, and the pharmacological modulation of the over-activity of this system could be useful in the treatment of the metabolic syndrome.Abstract:
Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960's, is Δ9-tetrahydrocannabinol. On the other hand, the discovery of cannabinoid receptors and their endogenous agonists took place only very recently. In fact, the first cannabinoid receptor (CB1) was cloned in 1990, followed 3 years later by the characterization of a second cannabinoid receptor (CB2). Since the 19th century, the use of cannabis has been reported to stimulate appetite and increase the consumption of sweet and tasty food, sometimes resulting in significant weight gain. The recent description of the endocannabinoid system, not only in the central nervous system but also in peripheral tissues, points to its involvement in the regulation of appetite, food intake and energy metabolism. Consequently, the pharmacological modulation of the over-activity of this system could be useful in the treatment of the metabolic syndrome. The endocannabinoid system has important physiological functions not only in the central nervous system but also in peripheral tissues. The activation of central CB1 receptors, particularly in hypothalamic nuclei and in the limbic system, is involved in the regulation of feeding behavior, and especially in the control of the intake of palatable food. In the periphery, cannabinoid receptors are present in adipocytes, skeletal muscle, gastrointestinal tract and liver, modulating energy metabolism.read more
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Adverse pregnancy outcomes in women with diabetes
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The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats.
Przemysław Adamczyk,Joanna Miszkiel,Andrew C. McCreary,Małgorzata Filip,Mariusz Papp,Edmund Przegaliński +5 more
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Instituto superior de ci ncias da sa⁄de
TL;DR: The regulation of feeding behavior also involves the monoamines dopamine, noradrenalin and serotonin involved in the reward center, a system that values the intake by the feeling of pleasure, and the endocannabinoid system that protects from anxiety and stimulates feeding.
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The endocannabinoid system: directing eating behavior and macronutrient metabolism
Bruce A. Watkins,Jeffrey Kim +1 more
TL;DR: The goal of this review is to assess the current available research on ECS and food intake, suggest research that may improve the complications associated with obesity and diabetes by dietary PUFA intervention, and further reveal mechanisms to elucidate the relationships between substrate for EC synthesis, ligand actions on receptors, and the physiological consequences of the ECS.
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The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders
TL;DR: It is difficult to associate plasmatic changes in ECS with specific endometrial and placental diseases, so pairing alterations in AEA levels with 2-AG and/or other endocannabinoid-like molecules may provide more accurate and early diagnoses.
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