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Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients.

TL;DR: The higher relative mortality risks identified among ER-/PR- patients with small or low-grade tumors raise the question of whether there may be a beneficial role for adjuvant chemotherapy in this population of women.
Journal ArticleDOI

Gene expression profiling in breast cancer: classification, prognostication, and prediction

TL;DR: In this paper, the conceptual effect and potential clinical use of the molecular classification of breast cancer, and discuss prognostic and predictive multigene predictors are discussed, and a molecular classification system and prognostic multi-genene classifiers based on microarrays or derivative technologies have been developed and are being tested in randomised clinical trials and incorporated into clinical practice.

Gene expression profi ling in breast cancer: classifi cation, prognostication, and prediction

TL;DR: In this paper, the conceptual effect and potential clinical use of the molecular classification of breast cancer, and discuss prognostic and predictive multigene predictors are discussed, and a molecular classification system and prognostic multi-genene classifiers based on microarrays or derivative technologies have been developed and are being tested in randomised clinical trials and incorporated into clinical practice.
Journal ArticleDOI

Early Breast Cancer Therapy and Cardiovascular Injury

TL;DR: Emerging evidence on the cardiovascular effects of breast cancer adjuvant therapy is reviewed and a new entity is proposed that is labeled the "multiple-hit" hypothesis, which may reduce a major cause of mortality in women with early breast cancer.
Journal ArticleDOI

A Decade of Rituximab: Improving Survival Outcomes in Non-Hodgkin's Lymphoma

TL;DR: The clinical development of rituximab-based therapies for patients with low-grade or follicular NHL and newly diagnosed DLBCL is discussed, highlighting recent key randomized trials with a focus on survival outcomes.
Related Papers (5)

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

O. Abe, +412 more
- 14 May 2005 -