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The diverse and complex roles of NF-κB subunits in cancer
TL;DR: If the NF-κB pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-σκB subunits.
Journal ArticleDOI
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
David S. Siegel,Thomas Martin,Michael Wang,Ravi Vij,Andrzej Jakubowiak,Sagar Lonial,Suzanne Trudel,Vishal Kukreti,Nizar J. Bahlis,Melissa Alsina,Asher Chanan-Khan,Francis K. Buadi,Frederic J. Reu,George Somlo,Jeffrey A. Zonder,Kevin W. Song,A. Keith Stewart,Edward A. Stadtmauer,Lori Kunkel,Sandra Wear,Alvin F. Wong,Robert Z. Orlowski,Sundar Jagannath +22 more
TL;DR: Durable responses and an acceptable tolerability profile in this heavily pretreated population demonstrate the potential of carfilzomib to offer meaningful clinical benefit.
Journal ArticleDOI
Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective.
Rodrigo E. González-Reyes,Mauricio O. Nava-Mesa,Karina Vargas-Sánchez,Daniel Ariza-Salamanca,Laura Mora-Muñoz +4 more
TL;DR: The Aβ/NF-κB interaction in astrocytes may play a central role in these inflammatory and OS changes present in AD, and therapeutic measures highlighting the importance of astroCytes in AD pathology are discussed.
Journal ArticleDOI
Aging and Immune Function: Molecular Mechanisms to Interventions
TL;DR: It is believed that a better understanding of the mechanisms underlying immune senescence will lead to an effective interventional strategy aimed at improving the health span of individuals.
Journal ArticleDOI
Regulation of autophagy by stress-responsive transcription factors.
Federico Pietrocola,V. Izzo,Mireia Niso-Santano,Mireia Niso-Santano,Erika Vacchelli,Erika Vacchelli,Lorenzo Galluzzi,Lorenzo Galluzzi,Maria Chiara Maiuri,Guido Kroemer +9 more
TL;DR: The molecular mechanisms whereby autophagy is orchestrated by stress-responsive transcription factors are discussed, which have been shown to play a major role in the regulation of both these phases of the autophagic response to stress.