Journal ArticleDOI
The plasminogen activation system in tumor growth, invasion, and metastasis.
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TLDR
The increased knowledge about the plasminogen activation system may allow utilization of its components as targets for anti-invasive therapy.Abstract:
Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen can be catalyzed by either of two other serine proteinases, the urokinase- and tissue-type plasminogen activators (uPA and tPA). The plasminogen activation system also includes the serpins PAI-1 and PAI-2, and the uPA receptor (uPAR). Many findings, gathered over several decades, strongly suggest an important and causal role for uPA-catalyzed plasmin generation in cancer cell invasion through the extracellular matrix. Recent evidence suggests that the uPA system is also involved in cancer cell-directed tissue remodeling. Moreover, the system also supports cell migration and invasion by plasmin-independent mechanisms, including multiple interactions between uPA, uPAR, PAI-1, extracellular matrix proteins, integrins, endocytosis receptors, and growth factors. These interactions seem to allow temporal and spatial reorganizations of the system during cell migration and a selective degradation of extracellular matrix proteins during invasion. The increased knowledge about the plasminogen activation system may allow utilization of its components as targets for anti-invasive therapy.read more
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Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
Geneviève Nguyen,Françoise Delarue,Céline Burcklé,Latifa Bouzhir,Thomas Giller,Jean-Daniel Sraer +5 more
TL;DR: The expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single transmembrane domain and no homology with any known membrane protein is reported, the first described for an aspartyl protease.
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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.
Ju Seog Lee,Jeonghoon Heo,Louis Libbrecht,In-Sun Chu,Pal Kaposi-Novak,Diego F. Calvisi,A. S. Mikaelyan,Lewis R. Roberts,Anthony J. Demetris,Zongtang Sun,Frederik Nevens,Tania Roskams,Snorri S. Thorgeirsson +12 more
TL;DR: Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development.
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Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis
TL;DR: A review examines the role of the matrix metalloproteinase (MMP) and plasminogen activator (PA)-plasmin systems during angiogenesis, finding a role for gelatinases, membrane-type 1 MMP, and PA inhibitor 1 has been clearly defined in a number of model systems.
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Obesity and Cancer: The Role of Dysfunctional Adipose Tissue
TL;DR: This article reviews mechanisms, focusing on adipose tissue dysfunction as a unifying causal factor in carcinogenesis and cancer progression, and concludes that preventing overweight and obesity still remains number one priority.
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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
TL;DR: It is reported that suppression of the p53 target gene encoding plasminogen activator inhibitor-1 (PAI-1) by RNA interference leads to escape from replicative senescence both in primary mouse embryo fibroblasts and primary human BJ fibro Blasts.
References
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Journal ArticleDOI
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Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
The urokinase-type plasminogen activator system in cancer metastasis: a review
TL;DR: Recent observations related to the molecular and cellular mechanisms underlying the role of the u‐PA system are discussed, suggesting that the system does not support tumor metastasis by the unrestricted enzyme activity of u‐ PA and plasmin and that pericellular molecular and functional interactions appear to allow temporal and spatial re‐organizations of the system during cell migration.