The platelet contribution to cancer progression.
N. M. Bambace,Chris E. Holmes +1 more
TLDR
Platelets provide a procoagulant surface facilitating amplification of cancer‐related coagulation, and can be recruited to shroud tumor cells, thereby shielding them from immune responses, and facilitate cancer growth and dissemination.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2011-02-01 and is currently open access. It has received 568 citations till now. The article focuses on the topics: Platelet activation & Platelet.read more
Citations
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Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
TL;DR: It is suggested that aspirin might help in treatment of some cancers and provides proof of principle for pharmacological intervention specifically to prevent distant metastasis in patients who developed cancer during trials of daily aspirin versus control.
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Platelet secretion: From haemostasis to wound healing and beyond
TL;DR: Current understanding of the roles of platelet secretion in health and disease is summarized, and some of the hypotheses that may explain how platelets may control the release of its many secreted components in a context-specific manner are discussed to allow platelets to play multiple roles in health.
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Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment
Jaehong Kim,Jong-Sup Bae +1 more
TL;DR: Tumor-associated macrophages and tumor-associated neutrophils can exert protumoral functions, enhancing tumor cell invasion and metastasis, angiogenesis, and extracellular matrix remodeling, while inhibiting the antitumoral immune surveillance.
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The Platelet Lifeline to Cancer: Challenges and Opportunities
Monika Haemmerle,Monika Haemmerle,Rebecca L. Stone,David G. Menter,Vahid Afshar-Kharghan,Anil K. Sood +5 more
TL;DR: A review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment is presented.
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The metastasis-promoting roles of tumor-associated immune cells
Heath A. Smith,Yibin Kang +1 more
TL;DR: This review focuses on the interactions between tumor cells and immune cells recruited to the tumor microenvironment and examines the factors allowing these cells to promote each stage of metastasis.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Matrix metalloproteinases and tumor metastasis
TL;DR: The major pieces of evidence that are most compelling and clearly determine the role and involvement of MMPs in the metastatic cascade are provided by molecular genetic studies employing knock-out or transgenic animals and tumor cell lines, modified to overexpress or downregulate a specific MMP.
Book
Hematology: Basic Principles and Practice
TL;DR: The author examines the immune system through the lens of Epstein-Barr Virus-Associated Diseases, as well as the biology of Stem Cells and Disorders of Hematopoiesis, and the approach to the Adult and Child with Anemia.
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Tumor Induction of VEGF Promoter Activity in Stromal Cells
Dai Fukumura,Ramnik J. Xavier,Takeyuki Sugiura,Yi Chen,Eun Chung Park,Naifang Lu,Martin K. Selig,Gunnlaugur P. Nielsen,Tatyana Taksir,Rakesh K. Jain,Brian Seed +10 more
TL;DR: The finding that the VEGF promoter of nontransformed cells is strongly activated by the tumor microenvironment points to a need to analyze and understand stromal cell collaboration in tumor angiogenesis.