Thematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue.
Timothy J. Bartness,C.K. Song +1 more
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TLDR
Functional evidence for the role of the SNS innervation in lipid mobilization in human WAT is convincing, with some controversy regarding the level of sympathetic nerve activity in human obesity.About:
This article is published in Journal of Lipid Research.The article was published on 2007-08-01 and is currently open access. It has received 200 citations till now. The article focuses on the topics: Sympathetic nervous system & Parasympathetic nervous system.read more
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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
TL;DR: It is postulate that this variability in the severity of insulin resistance varies greatly among obese people might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acid.
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Lipolysis and lipid mobilization in human adipose tissue
TL;DR: Endocrine and autocrine/paracrine factors cooperate and lead to a fine regulation of lipolysis in adipocytes, which has therapeutic potential in the metabolic disorders frequently associated with obesity and probably in several inborn errors of metabolism.
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Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications.
TL;DR: This chapter will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women.
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The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
Alessandra Vitali,Incoronata Murano,Maria Cristina Zingaretti,Andrea Frontini,Daniel Ricquier,Saverio Cinti +5 more
TL;DR: Quantitative analysis showed that cold acclimation induced an increase in brown adipocytes and an almost equal reduction in white adipocytes; however, there were no significant differences in total adipocyte count or any signs of apoptosis or mitosis, in line with the hypothesis of the direct transformation of white into Brown adipocytes.
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Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
Wenwen Zeng,Wenwen Zeng,Roksana M. Pirzgalska,Mafalda M.A. Pereira,Nadiya Kubasova,Andreia Barateiro,Andreia Barateiro,Elsa Seixas,Yi-Hsueh Lu,Albina Kozlova,Henning U. Voss,Gabriel G. Martins,Jeffrey M. Friedman,Jeffrey M. Friedman,Ana Domingos +14 more
TL;DR: It is found that sympathetic nerve fibers establish neuro-adipose junctions, necessary and sufficient for the induction of lipolysis in white adipose tissue and are an efferent effector of leptin action.
References
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Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
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Prevalence of Overweight and Obesity in the United States, 1999-2004
Cynthia L. Ogden,Margaret D. Carroll,Lester R. Curtin,Margaret McDowell,Carolyn J. Tabak,Katherine M. Flegal +5 more
TL;DR: These estimates suggest that the increases in body weight are continuing in men and in children and adolescents while they may be leveling off in women; among women, no overall increases in the prevalence of obesity were observed.
Book
The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
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Leptin and the regulation of body weight in mammals
TL;DR: The role of leptin in the control of body weight and its relevance to the pathogenesis of obesity are reviewed.