Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
TLDR
A comprehensive overview of pathways and players involved in the development of brown and beige fat as well as the role of thermogenic adipocytes in energy homeostasis and metabolism is provided.Abstract:
The concerning worldwide increase of obesity and chronic metabolic diseases, such as T2D, dyslipidemia, and cardiovascular disease, motivates further investigations into preventive and alternative therapeutic approaches. Over the past decade, there has been growing evidence that the formation and activation of thermogenic adipocytes (brown and beige) may serve as therapy to treat obesity and its associated diseases owing to its capacity to increase energy expenditure and to modulate circulating lipids and glucose levels. Thus, understanding the molecular mechanism of brown and beige adipocytes formation and activation will facilitate the development of strategies to combat metabolic disorders. Here, we provide a comprehensive overview of pathways and players involved in the development of brown and beige fat, as well as the role of thermogenic adipocytes in energy homeostasis and metabolism. Furthermore, we discuss the alterations in brown and beige adipose tissue function during obesity and explore the therapeutic potential of thermogenic activation to treat metabolic syndrome.read more
Citations
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The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
TL;DR: Current knowledge about the significant advances made in the origin and physiological functions of thermogenic fat is enumerated and imaging technologies for identifying thermogenic adipose tissue and pharmacologic agents via modulating thermogenesis in preclinical experiments and clinical trials are summarized.
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The Stress Axis in Obesity and Diabetes Mellitus: An Update
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Stefan Tholen,Roma H. Patel,Agnieszka Agas,Kyle M. Kovary,Atefeh Rabiee,Hayley T. Nicholls,Ewa Bielczyk-Maczyńska,Wenting Yang,Fredric B. Kraemer,Mary N. Teruel +9 more
TL;DR: In this paper , the authors flatten glucocorticoid oscillations in mice to prevent hyperinsulinemia and adipocyte hypertrophy, which leads to a more than 2-fold increase in brown and white adipose tissue mass within 3 weeks.
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Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases
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Sodium butyrate attenuated diet-induced obesity, insulin resistance and inflammation partly by promoting fat thermogenesis via intro-adipose sympathetic innervation
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