Thrombo-inflammation response to Tocilizumab in COVID-19.
Mansour Gergi,Mary Cushman,Benjamin Littenberg,Ralph C. Budd +3 more
- Vol. 4, Iss: 8, pp 1262-1268
TLDR
Observations have suggested that severe acute respiratory syndrome coronavirus 2 can provoke a hyperimmune response in some cases that could lead to secondary organ damage.Abstract:
Background: Coronavirus disease-19 (COVID-19) spans a wide spectrum of illness. Severe cases of COVID-19 can manifest inflammation in organs other than the lung, in tissues not known to support viral replication, and also in a hypercoagulable state. These observations have suggested that SARS-CoV-2 can provoke a hyperimmune response in some cases that could lead to secondary organ damage. Methods: With evidence of elevated levels of interleuking-6 (IL-6) in patients with severe COVID-19, we conducted a small pilot off-label compassionate care study of the IL-6 receptor inhibitor tocilizumab patients with severe COVID-19. Results: Following a single infusion of tocilizumab in patients with severe manifested rapid declines in C-reactive protein (CRP), D-Dimer, and gradual rises in lymphocyte and platelet counts. Conclusions: These findings suggest both pathophysiological mechanisms as well as clinical benefit that might be seen with IL-6 inhibition in severe COVID-19.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19.
Panagiotis Theofilis,Marios Sagris,Alexios S. Antonopoulos,Evangelos Oikonomou,Costas Tsioufis,Dimitris Tousoulis +5 more
TL;DR: In this paper, the impact of inflammation on platelet activation in atherosclerosis has been investigated and the role of pro-inflammatory cytokines has also been highlighted, such as platelet factor-4, myeloperoxidase, and platelet-derived mediators.
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