Journal ArticleDOI
Time zones: a comparative genetics of circadian clocks.
Michael W. Young,Steve A. Kay +1 more
TLDR
The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals, and the weight of evidence favours their independent evolutionary origins in different kingdoms.Abstract:
The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals. Intense genetic analysis during recent years has uncovered many of the components and molecular mechanisms comprising these clocks. Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms.read more
Citations
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Journal ArticleDOI
Coordination of circadian timing in mammals
TL;DR: Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
Journal ArticleDOI
Coordinated transcription of key pathways in the mouse by the circadian clock.
Satchidananda Panda,Marina P. Antoch,Brooke H. Miller,Andrew I. Su,Andrew I. Su,Andrew B. Schook,Marty Straume,Peter G. Schultz,Peter G. Schultz,Steve A. Kay,Steve A. Kay,Joseph S. Takahashi,John B. Hogenesch +12 more
TL;DR: Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
Journal ArticleDOI
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Seung Hee Yoo,Shin Yamazaki,Shin Yamazaki,Phillip L. Lowrey,Kazuhiro Shimomura,Caroline H. Ko,Caroline H. Ko,Ethan D. Buhr,Sandra M. Siepka,Hee Kyung Hong,Won Jun Oh,Ook Joon Yoo,Michael Menaker,Joseph S. Takahashi +13 more
TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.
Journal ArticleDOI
Life between clocks: daily temporal patterns of human chronotypes.
TL;DR: It is predicted that the timing of sleep has changed during industrialization and that a majority of humans are sleep deprived during the workweek, and the implications are far ranging concerning learning, memory, vigilance, performance, and quality of life.
Journal ArticleDOI
Social Jetlag: Misalignment of Biological and Social Time
TL;DR: In this paper, the authors explore how sleep quality and psychological wellbeing are associated with individual chronotype and/or social jetlag and find that late chronotypes show the largest differences in sleep timing between work and free days leading to a considerable sleep debt on work days, for which they compensate on free days.
References
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Journal ArticleDOI
Clock Mutants of Drosophila melanogaster
Ronald J. Konopka,Seymour Benzer +1 more
TL;DR: Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed and all these mutations appear to involve the same functional gene on the X chromosome.
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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Francesca Damiola,Nguyet Le Minh,Nicolas Preitner,Benoît Kornmann,Fabienne Fleury-Olela,Ueli Schibler +5 more
TL;DR: It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
Journal ArticleDOI
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
Journal ArticleDOI
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
TL;DR: The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals, and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus.
Journal ArticleDOI
Entrainment of the Circadian Clock in the Liver by Feeding
TL;DR: It is demonstrated that feeding cycles can entrain the liver independently of the SCN and the light cycle, and the need to reexamine the mammalian circadian hierarchy is suggested, raising the possibility that peripheral circadian oscillators like those in the liver may be coupled to theSCN primarily through rhythmic behavior, such as feeding.