Timing of Antiretroviral Therapy for HIV-1 Infection and Tuberculosis
Diane V. Havlir,Michelle A. Kendall,Prudence Ive,Johnstone Kumwenda,Susan Swindells,Sarojini S. Qasba,Anne F Luetkemeyer,Evelyn Hogg,James F. Rooney,Xingye Wu,Mina C. Hosseinipour,Umesh G. Lalloo,Valdilea G. Veloso,Fatuma Some,N. Kumarasamy,Nesri Padayatchi,Breno Santos,Stewart E Reid,James Hakim,Lerato Mohapi,Peter Mugyenyi,Jorge Sanchez,Javier R. Lama,Jean W. Pape,Alejandro Sanchez,Aida Asmelash,Evans Moko,Fred Sawe,Janet Andersen,Ian Sanne +29 more
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TLDR
In persons with CD4+ T-cell counts of less than 50 per cubic millimeter, earlier ART was associated with a lower rate of new AIDS-defining illnesses and death, as compared with later ART.Abstract:
Background Antiretroviral therapy (ART) is indicated during tuberculosis treatment in patients infected with human immunodeficiency virus type 1 (HIV-1), but the timing for the initiation of ART wh...read more
Citations
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Journal ArticleDOI
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.
Payam Nahid,Susan E. Dorman,Narges Alipanah,Pennan M. Barry,Jan Brozek,Adithya Cattamanchi,Lelia H. Chaisson,Richard E. Chaisson,Charles L. Daley,M. Grzemska,Julie Higashi,Christine S Ho,Philip C. Hopewell,Salmaan Keshavjee,Christian Lienhardt,Richard Menzies,Cynthia Merrifield,Masahiro Narita,Rick O'Brien,Charles A. Peloquin,Ann Raftery,Jussi J. Saukkonen,H. Simon Schaaf,Giovanni Sotgiu,Jeffrey R. Starke,Giovanni Battista Migliori,Andrew Vernon +26 more
TL;DR: This guideline provides recommendations on the clinical and public health management of tuberculosis in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis.
Journal ArticleDOI
Advances in the development of new tuberculosis drugs and treatment regimens
TL;DR: Current concepts and recent advances in TB drug discovery and development are covered, including an update of ongoing TB treatment trials, newer clinical trial designs, TB biomarkers and adjunct host-directed therapies.
Journal ArticleDOI
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society–USA Panel
Huldrych F. Günthard,Michael S. Saag,Constance A. Benson,Carlos del Rio,Joseph J. Eron,Joel E. Gallant,Jennifer F Hoy,Michael J. Mugavero,Paul E. Sax,Melanie A. Thompson,Rajesh T. Gandhi,Raphael J. Landovitz,Davey M. Smith,Donna M. Jacobsen,Paul A. Volberding +14 more
TL;DR: In this article, the authors provide updated recommendations for the use of antiretroviral therapy in adults (aged ≥18 years) with established HIV infection, including when to start treatment, initial regimens, and changing regimens along with recommendations for using ARVs for preventing HIV among those at risk, including preexposure and postexposure prophylaxis.
Journal ArticleDOI
Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis
François-Xavier Blanc,Thim Sok,Didier Laureillard,Laurence Borand,Claire Rekacewicz,Eric Nerrienet,Yoann Madec,Olivier Marcy,Sarin Chan,Narom Prak,Chindamony Kim,Khemarin Kim Lak,Chanroeurn Hak,Bunnet Dim,Chhun Im Sin,Sath Sun,Bertrand Guillard,Borann Sar,Sirenda Vong,Marcelo Fernandez,Larry A. Fox,Jean-François Delfraissy,Anne E. Goldfeld +22 more
TL;DR: Starting antiretroviral therapy 2 weeks after the start of tuberculosis treatment significantly improved survival among HIV-infected adults with CD4+ T-cell counts of 200 per cubic millimeter or lower.
Journal ArticleDOI
Health in South Africa: changes and challenges since 2009
Bongani M. Mayosi,Joy E Lawn,Ashley van Niekerk,Ashley van Niekerk,Debbie Bradshaw,Salim S. Abdool Karim,Salim S. Abdool Karim,Hoosen M. Coovadia,Hoosen M. Coovadia +8 more
TL;DR: Transformation of the health system into a national institution that is based on equity and merit and is built on an effective human-resources system could still place South Africa on track to achieve Millennium Development Goals 4, 5, and 6 and would enhance the lives of its citizens.
References
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Nonparametric Estimation from Incomplete Observations
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Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis
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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.
Graeme Meintjes,Stephen D. Lawn,Stephen D. Lawn,Fabio Scano,Gary Maartens,Martyn A. French,William Worodria,Julian Elliott,David M Murdoch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Catherine Seyler,Laurence John,Maarten F. Schim van der Loeff,Peter Reiss,Lut Lynen,Edward N. Janoff,Charles F. Gilks,Robert Colebunders,Robert Colebunders +20 more