Journal ArticleDOI
Advances in the development of new tuberculosis drugs and treatment regimens
TLDR
Current concepts and recent advances in TB drug discovery and development are covered, including an update of ongoing TB treatment trials, newer clinical trial designs, TB biomarkers and adjunct host-directed therapies.Abstract:
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide. For the first time since the 1960s, new and novel drugs and regimens for all forms of TB are emerging. Such regimens are likely to utilize both repurposed drugs and new chemical entities, and several of these regimens are now progressing through clinical trials. This article covers current concepts and recent advances in TB drug discovery and development, including an update of ongoing TB treatment trials, newer clinical trial designs, TB biomarkers and adjunct host-directed therapies.read more
Citations
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Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.
Payam Nahid,Susan E. Dorman,Narges Alipanah,Pennan M. Barry,Jan Brozek,Adithya Cattamanchi,Lelia H. Chaisson,Richard E. Chaisson,Charles L. Daley,M. Grzemska,Julie Higashi,Christine S Ho,Philip C. Hopewell,Salmaan Keshavjee,Christian Lienhardt,Richard Menzies,Cynthia Merrifield,Masahiro Narita,Rick O'Brien,Charles A. Peloquin,Ann Raftery,Jussi J. Saukkonen,H. Simon Schaaf,Giovanni Sotgiu,Jeffrey R. Starke,Giovanni Battista Migliori,Andrew Vernon +26 more
TL;DR: This guideline provides recommendations on the clinical and public health management of tuberculosis in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis.
Journal ArticleDOI
Towards tuberculosis elimination: an action framework for low-incidence countries
Knut Lönnroth,Giovanni Battista Migliori,Ibrahim Abubakar,Lia D'Ambrosio,Gerard De Vries,Roland Diel,Paul Douglas,Dennis Falzon,Marc Andre Gaudreau,Delia Goletti,Edilberto R. González Ochoa,Philip A. LoBue,Alberto Matteelli,Howard Njoo,Ivan Solovic,Alistair Story,Tamara Tayeb,Marieke J. van der Werf,Diana Weil,Jean-Pierre Zellweger,Mohamed Abdel Aziz,Mohamed R.M. Al Lawati,Stefano Aliberti,Wouter Arrazola de Oñate,Draurio Barreira,Vineet Bhatia,Francesco Blasi,Amy Bloom,Judith Bruchfeld,Francesco Castelli,Rosella Centis,Daniel Chemtob,Daniela Maria Cirillo,Alberto Colorado,Andrei Dadu,Ulf R Dahle,Laura De Paoli,Hannah Monica Yesudian Dias,Raquel Duarte,Lanfranco Fattorini,Mina Gaga,Haileyesus Getahun,Philippe Glaziou,Lasha Goguadze,Mirtha del Granado,Walter Haas,Asko Järvinen,Geun Yong Kwon,Davide Mosca,Payam Nahid,Nobuyuki Nishikiori,I. Noguer,Joan O'Donnell,Analita Pace-Asciak,Maria Grazia Pompa,Gilda Popescu,Carlos Robalo Cordeiro,Karin Rønning,Morten Ruhwald,Jean-Paul Sculier,Aleksandar Simunovic,Alison Smith-Palmer,Giovanni Sotgiu,Giorgia Sulis,Carlos A. Torres-Duque,Kazunori Umeki,Mukund Uplekar,Catharina Van Weezenbeek,Tuula Vasankari,Robert J. Vitillo,Constantia Voniatis,Maryse Wanlin,Mario C. Raviglione +72 more
TL;DR: An action framework for countries with low tuberculosis (TB) incidence sets out priority interventions required for these countries to progress first towards “pre-elimination” and eventually the elimination of TB as a public health problem.
Journal ArticleDOI
Antibiotics in the clinical pipeline in 2013
TL;DR: The continued emergence of multi-drug-resistant bacteria is a major public health concern and the identification and development of new antibiotics, especially those with new modes of action, is imperative to help treat these infections.
Journal ArticleDOI
Metformin as adjunct antituberculosis therapy
Amit Singhal,Liu Jie,Pavanish Kumar,Gan Suay Hong,Melvin Khee-Shing Leow,Melvin Khee-Shing Leow,Bhairav Paleja,Liana Tsenova,Liana Tsenova,Natalia Kurepina,Jinmiao Chen,Francesca Zolezzi,Barry N. Kreiswirth,Michael Poidinger,Michael Poidinger,Cynthia B.E. Chee,Gilla Kaplan,Gilla Kaplan,Yee Tang Wang,Gennaro De Libero,Gennaro De Libero +20 more
TL;DR: It is reported that the antidiabetic drug metformin (MET) reduces the intracellular growth of Mycobacterium tuberculosis (Mtb) in an AMPK (adenosine monophosphate–activated protein kinase)–dependent manner, and controls the growth of drug-resistant Mtb strains.
Journal ArticleDOI
Heterogeneity in tuberculosis
TL;DR: This Review draws on model systems and human data to discuss multiple facets of TB biology and their relationship to the overall heterogeneity observed in the human disease.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis.
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Journal ArticleDOI
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Neel R. Gandhi,Neel R. Gandhi,Anthony P. Moll,A. Willem Sturm,Robert Pawinski,Thiloshini Govender,Umesh G. Lalloo,Kimberly Zeller,Kimberly Zeller,Jason R. Andrews,Gerald Friedland +10 more
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Journal ArticleDOI
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TL;DR: The biology of latent tuberculosis is discussed as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide microenvironments with differential ability to support or suppress the persistence of viable bacteria.
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