Journal ArticleDOI
TNF-α inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L.
TLDR
Compounds 1, 5-7, 9-10, and 13 showed anti-inflammatory potency to suppress expression of NF-κB and AP-1 targeted genes including TNF-α and IL-6 induced by lipopolysaccharide (LPS) in mouse macrophages Raw 264.7 cells.About:
This article is published in Phytochemistry.The article was published on 2010-12-01. It has received 48 citations till now. The article focuses on the topics: Excoecaria agallocha.read more
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Review: Marine natural products
TL;DR: This review covers the literature published in 2010 for marine natural products, with 895 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves-A Comprehensive Review.
Sadeer Nabeelah Bibi,Mahomoodally Mohamad Fawzi,Zengin Gokhan,Jeewon Rajesh,Nazurally Nadeem,Rengasamy Kannan R R,Albuquerque R D D G,Shunmugiah Karutha Pandian +7 more
TL;DR: This review aims to provide a comprehensive account of the morphological characteristics, ethnobotany, global distribution, taxonomy, ethnopharmacology, phytochemical profiles, and pharmacological activities of traditionally used mangroves.
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Diterpenoids of terrestrial origin
TL;DR: This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products.
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Total Synthesis of Atisane-Type Diterpenoids: Application of Diels–Alder Cycloadditions of Podocarpane-Type Unmasked ortho-Benzoquinones
TL;DR: Based on this methodology, divergent total syntheses of atisane-type diterpenoids, including (±)-crotobarin, crotogoudin, at isane-3β,16α-diol, and 16S,17-dihydroxy-atisan-3-one, were accomplished in 14, 14, 12, and16 steps, respectively.
References
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Journal ArticleDOI
Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential
TL;DR: Folk medicine supports the studies which have demonstrated that plant-derived terpenoid ingredients can suppress nuclear factor-κB signaling, the major regulator in the pathogenesis of inflammatory diseases and cancer.
Journal Article
Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9.
TL;DR: There is significant evidence that whole green tea is a more reasonable mixture of tea polyphenols for cancer prevention in humans than EGCG alone and that it is even more effective when it is used in combination with other cancer preventives.
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Kaurane Diterpene, Kamebakaurin, Inhibits NF-κB by Directly Targeting the DNA-binding Activity of p50 and Blocks the Expression of Antiapoptotic NF-κB Target Genes
TL;DR: It is demonstrated that kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50 by directly covalent modification of cysteine 62 in the p50.
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Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta).
TL;DR: The description of an extensive microsatellite polymorphic system which should provide a more definitive understanding of the association of the TNF locus with disease is described.