Journal ArticleDOI
Toward a unified nomenclature for mammalian ADP-ribosyltransferases
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TLDR
A new consensus nomenclature for all ADP-ribosyltransferases (ARTs) based on the catalyzed reaction and on structural features is proposed to facilitate communication between researchers both inside and outside the ADP, ribosylation field.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2010-04-01. It has received 736 citations till now.read more
Citations
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs.
Bryan A. Gibson,W. Lee Kraus +1 more
TL;DR: This work has shown that the activity of PARP family members, such as PARP1 and PARP2, is tied to cellular signalling pathways, and through poly(ADP-ribosyl)ation (PARylation) they ultimately promote changes in gene expression, RNA and protein abundance, and the location and activity of proteins that mediate signalling responses.
Journal ArticleDOI
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
Raga Krishnakumar,W. Lee Kraus +1 more
TL;DR: The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus.
Journal ArticleDOI
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
TL;DR: New findings on the diverse roles of PARPs in chromatin regulation, transcription, RNA biology, and DNA repair have been complemented by recent advances that link ADP-ribosylation to stress responses, metabolism, viral infections, and cancer.
Journal ArticleDOI
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Elisabet Wahlberg,Tobias Karlberg,Ekaterina Kouznetsova,Ekaterina Kouznetsova,N. Markova,N. Markova,Antonio Macchiarulo,Ann-Gerd Thorsell,Ewa Pol,Åsa Frostell,T. Ekblad,Delal Öncü,Björn Kull,Graeme M. Robertson,Roberto Pellicciari,Herwig Schüler,J. Weigelt +16 more
TL;DR: Evaluated small-molecule inhibitors of poly-ADP-ribose polymerase (PARP) family proteins showed that the majority of PARP inhibitors bind multiple targets, providing insight into the design of new inhibitors.
Journal ArticleDOI
NAD+ metabolism and its roles in cellular processes during ageing
Anthony J. Covarrubias,Anthony J. Covarrubias,Rosalba Perrone,Alessia Grozio,Eric Verdin,Eric Verdin +5 more
TL;DR: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism and is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases as discussed by the authors.
References
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Journal ArticleDOI
The PARP superfamily.
TL;DR: This review summarizes the present knowledge of this emerging superfamily of Poly(ADP‐ribose) polymerases, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders.
Journal ArticleDOI
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
Marcia C. Haigis,Raul Mostoslavsky,Kevin M. Haigis,Kamau Fahie,Danos C. Christodoulou,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Margaret Karow,Gil Blander,Cynthia Wolberger,Tomas A. Prolla,Richard Weindruch,Frederick W. Alt,Leonard Guarente +14 more
TL;DR: It is shown that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR.
Journal ArticleDOI
Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres
TL;DR: Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP), was identified and localized to human telomeres.
Journal ArticleDOI
NAD+ metabolism in health and disease.
TL;DR: Nicotinamide riboside, the recently discovered nucleoside precursor of NAD(+ in eukaryotic systems, might have advantages as a therapy to elevate NAD(+) without inhibiting sirtuins, which is associated with high-dose nicotinamide, or incurring the unpleasant side-effects of high- dose nicotinic acid.
Journal ArticleDOI
Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system
Dan Cassel,Thomas Pfeuffer +1 more
TL;DR: The results indicate that cholera toxin affects the adenylate cyclase system by catalyzing an ADP-ribosylation of the 42,000-M(r) component bearing the guanyl nucleotide regulatory site.
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs.
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