Traffic-related air pollution, particulate matter, and autism.
TLDR
Exposure to traffic-related air pollution, nitrogen dioxide, PM2.5, and PM10 during pregnancy and during the first year of life was associated with autism.Citations
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Journal ArticleDOI
Cerebral cortex and blood transcriptome changes in mouse neonates prenatally exposed to air pollution particulate matter
Amin Haghani,Amin Haghani,Jason I. Feinberg,Kristy Lewis,Christine Ladd-Acosta,Richard G. Johnson,Andrew E. Jaffe,Constantinos Sioutas,Caleb E. Finch,Daniel B. Campbell,Todd E. Morgan,Heather E. Volk +11 more
TL;DR: In this article, RNA sequencing was used to examine transcriptomic changes in blood and cerebral cortex of three male and three female mouse neonates prenatally exposed to traffic-related nano-sized particulate matter (nPM) compared to three male, three female, and three male mice neonates exposed to control filter air.
Proceedings ArticleDOI
Uncovering the etiology of autism spectrum disorders: genomics, bioinformatics, environment, data collection and exploration, and future possibilities.
TL;DR: An introduction to the current state of autism research is provided, highlighting the potential for multi-disciplinary collaborations that rigorously evaluate the many potential contributors to ASD and approaches that successfully advance the understanding can be applied to the study of other common, complex disorders.
Dissertation
Identification of biobehavioral markers of neurodevelopmental disorders in twins
TL;DR: The results support that systemic preand postnatal elemental dysregulation increase ASD risk, and an association between early medical events and ASD risk is found, and point to a cumulative multifactor threshold model, including both genetic and NSE components in the etiology of ASD.
Journal ArticleDOI
Air Pollution and ASDs: A Deeper Dive into an Environmental Risk Factor.
TL;DR: Of the potential environmental risk factors for ASDs identified in the past 12 years, air pollution may be the most studied, says a new study, which examined the potential effects of 155 hazardous air pollutants on ASD diagnosis and severity.
References
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Journal ArticleDOI
Mullen Scales of Early Learning
TL;DR: The Mullen Scales of Early Learning (MSEL) as mentioned in this paper includes five scales that provide information on cognitive and motor ability, including Gross Motor (0-33 months only), Visual Reception, Fine Motor, Expressive Language and Receptive Language.
Journal ArticleDOI
Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells
Marianne Geiser,Barbara Rothen-Rutishauser,Nadine Kapp,Samuel Schürch,Samuel Schürch,Wolfgang G. Kreyling,Holger Schulz,Manuela Semmler,Vinzenz Im Hof,Joachim Heyder,Peter Gehr +10 more
TL;DR: Inhaled ultrafine titanium dioxide particles were found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries, while particle uptake in vitro did not occur by any of the expected endocytic processes, but rather by diffusion or adhesive interactions.
Prevalence of Autism Spectrum Disorders: Autism and Developmental Disabilities Monitoring Network, United States, 2006. Morbidity and Mortality Weekly Report. Surveillance Summaries. Volume 58, Number SS-10.
TL;DR: The identified prevalence of ASDs in U.S. children aged 8 years was estimated through a systematic retrospective review of evaluation records in multiple sites participating in the Autism and Developmental Disabilities Monitoring (ADDM) Network and presence of an identified ASD was determined through a review of data abstracted from developmental evaluation records by trained clinician reviewers.
Journal ArticleDOI
Air pollution: mechanisms of neuroinflammation and CNS disease
TL;DR: Recent findings detailing the mechanisms through which air pollution reaches the brain and activates the resident innate immune response to become a chronic source of pro-inflammatory factors and ROS, culminating in CNS disease are summarized.