Traffic-related air pollution, particulate matter, and autism.
TLDR
Exposure to traffic-related air pollution, nitrogen dioxide, PM2.5, and PM10 during pregnancy and during the first year of life was associated with autism.Citations
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Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
Jane C. Naviaux,Lin Wang,Kefeng Li,A. Taylor Bright,William A. Alaynick,Kenneth R Williams,Kenneth R Williams,Susan B. Powell,Susan B. Powell,Robert K. Naviaux +9 more
TL;DR: The data show that antipurinergic therapy improves the multisystem, ASD-like features of both the environmental MIA, and the genetic Fragile X models.
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Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.
Sylvie Tordjman,Sylvie Tordjman,Eszter Somogyi,Nathalie Coulon,Solenn Kermarrec,Solenn Kermarrec,David Cohen,Guillaume Bronsard,Olivier Bonnot,Catherine Weismann-Arcache,Michel Botbol,Michel Botbol,Bertrand Lauth,Vincent Ginchat,Pierre L. Roubertoux,Marianne Barbu-Roth,Viviane Kovess,Marie-Maude Geoffray,Jean Xavier +18 more
TL;DR: Arguments for a genetic contribution to autism, based on updated family and twin studies, are examined and the possible role of epigenetic mechanisms reported in genetic disorders associated with ASD is discussed.
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Multiple Threats to Child Health from Fossil Fuel Combustion: Impacts of Air Pollution and Climate Change
TL;DR: This commentary summarizes the robust scientific evidence regarding the multiple current and projected health impacts of fossil fuel combustion on the young to make the case for a holistic, child-centered energy and climate policy that addresses the full array of physical and psychosocial stressors resulting from fossil fuel pollution.
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Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.
TL;DR: The goal of this review is to highlight the broader implications of Dr. Patterson's work for the field of autism, with a focus on the impact that MIA by diverse environmental factors has on fetal brain development, immune system development, and the pathophysiology of ASD.
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Fine Particulate Matter Air Pollution and Cognitive Function Among Older US Adults
TL;DR: This study examines the cross-sectional association between residential concentrations of particulate matter with aerodynamic diameter of 2.5 μm or less and cognitive function in older adults and suggests that the association is strongest for the episodic memory component of cognitive function.
References
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Mullen Scales of Early Learning
TL;DR: The Mullen Scales of Early Learning (MSEL) as mentioned in this paper includes five scales that provide information on cognitive and motor ability, including Gross Motor (0-33 months only), Visual Reception, Fine Motor, Expressive Language and Receptive Language.
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Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells
Marianne Geiser,Barbara Rothen-Rutishauser,Nadine Kapp,Samuel Schürch,Samuel Schürch,Wolfgang G. Kreyling,Holger Schulz,Manuela Semmler,Vinzenz Im Hof,Joachim Heyder,Peter Gehr +10 more
TL;DR: Inhaled ultrafine titanium dioxide particles were found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries, while particle uptake in vitro did not occur by any of the expected endocytic processes, but rather by diffusion or adhesive interactions.
Prevalence of Autism Spectrum Disorders: Autism and Developmental Disabilities Monitoring Network, United States, 2006. Morbidity and Mortality Weekly Report. Surveillance Summaries. Volume 58, Number SS-10.
TL;DR: The identified prevalence of ASDs in U.S. children aged 8 years was estimated through a systematic retrospective review of evaluation records in multiple sites participating in the Autism and Developmental Disabilities Monitoring (ADDM) Network and presence of an identified ASD was determined through a review of data abstracted from developmental evaluation records by trained clinician reviewers.
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Air pollution: mechanisms of neuroinflammation and CNS disease
TL;DR: Recent findings detailing the mechanisms through which air pollution reaches the brain and activates the resident innate immune response to become a chronic source of pro-inflammatory factors and ROS, culminating in CNS disease are summarized.