Traffic-related air pollution, particulate matter, and autism.
TLDR
Exposure to traffic-related air pollution, nitrogen dioxide, PM2.5, and PM10 during pregnancy and during the first year of life was associated with autism.Citations
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Neurodegenerative and neurological disorders by small inhaled particles.
Harm J. Heusinkveld,Tina Wahle,Arezoo Campbell,Remco H.S. Westerink,Lang Tran,Helinor Jane Johnston,Vicki Stone,Flemming R. Cassee,Roel P. F. Schins +8 more
TL;DR: Outdoor air pollution has been linked to several health effects including oxidative stress and neuroinflammation that may ultimately result in neurodegeneration and cognitive impairment and this review aims to evaluate the relationship between exposure to inhaled ambient particles and neurodegenersation.
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Air Pollution and Neuropsychological Development: A Review of the Latest Evidence
TL;DR: In this article, the authors reviewed the latest epidemiologic literature on the association between outdoor air pollution and neuropsychological developmental in children and found sufficient evidence of detrimental effects of pre- or postnatal exposure to polycyclic aromatic hydrocarbons on global intelligence quotient.
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Environmental chemical exposures and autism spectrum disorders: a review of the epidemiological evidence.
TL;DR: Future research that addresses these and additional environmental chemicals, including their most common routes of exposures, with accurate exposure measurement pertaining to several developmental windows, is essential to guide efforts for the prevention of the neurodevelopmental damage that manifests in autism symptoms.
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Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.
William Mandy,Meng-Chuan Lai +1 more
TL;DR: Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene-environment interplay, and longitudinal studies to elucidate how rGE plays out over time.
aaaaaaaaa. Air Pollution and Neuropsychological Development: A Review of the Latest Evidence
TL;DR: The latest epidemiological studies support the hypothesis that pre- or postnatal exposure to ambient pollution, particularly polycyclic aromatic hydrocarbons, PM2.5, and nitrogen oxides has a negative impact on the neuropsychological development of children.
References
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Mullen Scales of Early Learning
TL;DR: The Mullen Scales of Early Learning (MSEL) as mentioned in this paper includes five scales that provide information on cognitive and motor ability, including Gross Motor (0-33 months only), Visual Reception, Fine Motor, Expressive Language and Receptive Language.
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Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells
Marianne Geiser,Barbara Rothen-Rutishauser,Nadine Kapp,Samuel Schürch,Samuel Schürch,Wolfgang G. Kreyling,Holger Schulz,Manuela Semmler,Vinzenz Im Hof,Joachim Heyder,Peter Gehr +10 more
TL;DR: Inhaled ultrafine titanium dioxide particles were found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries, while particle uptake in vitro did not occur by any of the expected endocytic processes, but rather by diffusion or adhesive interactions.
Prevalence of Autism Spectrum Disorders: Autism and Developmental Disabilities Monitoring Network, United States, 2006. Morbidity and Mortality Weekly Report. Surveillance Summaries. Volume 58, Number SS-10.
TL;DR: The identified prevalence of ASDs in U.S. children aged 8 years was estimated through a systematic retrospective review of evaluation records in multiple sites participating in the Autism and Developmental Disabilities Monitoring (ADDM) Network and presence of an identified ASD was determined through a review of data abstracted from developmental evaluation records by trained clinician reviewers.
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Air pollution: mechanisms of neuroinflammation and CNS disease
TL;DR: Recent findings detailing the mechanisms through which air pollution reaches the brain and activates the resident innate immune response to become a chronic source of pro-inflammatory factors and ROS, culminating in CNS disease are summarized.