Transition from acute to chronic postsurgical pain: risk factors and protective factors
Joel Katz,Ze'ev Seltzer +1 more
TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.Abstract:
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...read more
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Journal ArticleDOI
Causes and prevention of chronic postsurgical pain.
TL;DR: Surgical incision invariably causes some measure of nerve damage and inflammatory response that, in most cases, heals quickly without long-term negative consequence, but a subset of patients go on to develop lasting neuropathic pain that is difficult to treat and, in many cases, impossible to treat.
Journal ArticleDOI
Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.
Dale J. Langford,Steven M. Paul,Claudia West,Laura B. Dunn,Jon D. Levine,Kord M. Kober,Marylin J. Dodd,Christine Miaskowski,Bradley E. Aouizerat +8 more
TL;DR: Findings suggest that variations in potassium channel genes are associated with both mild and severe persistent breast pain after breast cancer surgery, and provide intriguing preliminary information on potential therapeutic targets.
Journal ArticleDOI
Opioid weaning and pain management in postsurgical patients at the Toronto General Hospital Transitional Pain Service
Hance Clarke,Hance Clarke,Saam Azargive,Saam Azargive,Janice Montbriand,Judith Nicholls,Ainsley M. Sutherland,Liliya Valeeva,Sherif Boulis,Kayla McMillan,Salima S.J. Ladak,Salima S.J. Ladak,Karim S. Ladha,Rita Katznelson,Karen McRae,Diana Tamir,Sheldon Lyn,Alexander Huang,Aliza Weinrib,Joel Katz,Joel Katz,Joel Katz +21 more
TL;DR: The Toronto General Hospital Transitional Pain Service successfully targets perioperative opioid use in complex pain patients and enabled almost half of opioid-naïve patients and one in four opioid-experienced patients to wean.
Journal ArticleDOI
Short-Term Sleep Disturbance–Induced Stress Does not Affect Basal Pain Perception, but Does Delay Postsurgical Pain Recovery
Po Kai Wang,Po Kai Wang,Jing Cao,Jing Cao,Hongzhen Wang,Lingli Liang,Jun Zhang,Brianna Marie Lutz,Kun Ruey Shieh,Alex Bekker,Yuan Xiang Tao +10 more
TL;DR: It is reported that pre- or postexposure to rapid eye movement sleep disturbance (REMSD) for 6 hours daily for 3 consecutive days did not alter basal responses to mechanical, heat, and cold stimuli, but did delay recovery in incision-induced reductions in paw withdrawal threshold to mechanical stimulation and paw withdrawal latencies to heat andcold stimuli.
Journal ArticleDOI
The pathophysiology, incidence, impact, and treatment of opioid-induced nausea and vomiting
TL;DR: The underlying mechanisms, clinical implications, and treatment strategies of OINV are discussed, which can lead to complications including electrolyte imbalances, malnutrition, and volume depletion, and can also negatively affect quality of life and postoperative recovery.
References
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Journal ArticleDOI
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis
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