Transition from acute to chronic postsurgical pain: risk factors and protective factors
Joel Katz,Ze'ev Seltzer +1 more
TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.Abstract:
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...read more
Citations
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Recovery 3 and 12 months after hysterectomy: epidemiology and predictors of chronic pain, physical functioning, and global surgical recovery.
Maurice Theunissen,Madelon L. Peters,Jan Schepers,Jacques W.M. Maas,Fleur Tournois,Hans A van Suijlekom,Hans-Fritz Gramke,Marco A. E. Marcus +7 more
TL;DR: Several predictors were identified for CPSP, physical functioning, and global surgical recovery and some of the identified factors are modifiable and optimization of patients’ preoperative pain status and psychological condition as well as reduction of acute postsurgical pain and surgery-related infection may lead to improvement of outcome.
Journal ArticleDOI
Perioperative gabapentin for the prevention of persistent pain after thoracotomy: a randomized controlled trial
Kasper Grosen,Asbjørn Mohr Drewes,Anette Højsgaard,Mogens Pfeiffer-Jensen,Vibeke E. Hjortdal,Hans K. Pilegaard +5 more
TL;DR: No evidence is found for the superiority of gabapentin over placebo for the treatment of acute pain following thoracotomy or for the prevention of persistent post-thoracotomy pain.
Journal ArticleDOI
Genetics of chronic post-surgical pain: a crucial step toward personal pain medicine
Hance Clarke,Hance Clarke,Joel Katz,Joel Katz,Joel Katz,Herta Flor,Marcella Rietschel,Scott R. Diehl,Ze'ev Seltzer,Ze'ev Seltzer +9 more
TL;DR: An update on the current state of CPSP genetics and its future potential is provided to provide an opportunity to expand knowledge in CPSP treatment that may manifest in a personalized approach to diagnosis, prevention, and therapy.
Journal ArticleDOI
Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes - a systematic review and meta-analysis.
TL;DR: It is suggested that propofol improves postoperative analgesia compared with inhalational anaesthesia 24 h after surgery, with a lower incidence of nausea and vomiting.
Journal ArticleDOI
Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human.
Manuel P. Pereira,Renee R. Donahue,Jørgen B. Dahl,Marianne Werner,Bradley K. Taylor,Mads U. Werner +5 more
TL;DR: Using a C57BL/6 mouse model of cutaneous mild heat injury (MHI), a dose-dependent reinstatement of pain sensitization is demonstrated and future exploratory studies in humans should prioritize inclusion of “high-sensitizers” prone to develop LS and use post-surgical models to elucidate markers of vulnerability to chronic postsurgical pain.
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