Transition from acute to chronic postsurgical pain: risk factors and protective factors
Joel Katz,Ze'ev Seltzer +1 more
TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.Abstract:
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...read more
Citations
More filters
Journal ArticleDOI
Rates and risk factors for prolonged opioid use after major surgery: population based cohort study
Hance Clarke,Neilesh Soneji,Neilesh Soneji,Dennis T. Ko,Dennis T. Ko,Lingsong Yun,Duminda N. Wijeysundera +6 more
TL;DR: Specific patient and surgical characteristics were associated with the development of prolonged postoperative use of opioids, and these findings can help better inform understanding about the long term risks of opioid treatment for acute postoperative pain.
Journal ArticleDOI
Poorly controlled postoperative pain: prevalence, consequences, and prevention
TL;DR: Several new opioids have been developed that modulate μ-receptor activity by selectively engaging intracellular pathways associated with analgesia and not those associated with adverse events, creating a wider therapeutic window than unselective conventional opioids.
Journal ArticleDOI
What we know about primary dysmenorrhea today: a critical review
TL;DR: The extensive multi-factorial impact of dysmenorrhea is demonstrated, evident even in phases of the menstrual cycle when women are not experiencing menstrual pain, illustrating that long-term differences in pain perception extend outside of the painful menstruation phase.
Journal ArticleDOI
Treatment of acute postoperative pain
TL;DR: This work examines the development of new analgesic agents and treatment modalities and regimens for acute postoperative pain, and investigates the use of specific analgesic techniques such as regional analgesia to improve patient outcomes.
References
More filters
Journal ArticleDOI
Five‐year follow‐up of a randomized trial to assess pain and numbness after laparoscopic or open repair of groin hernia
TL;DR: Claims that laparoscopic groin hernia repair is followed by less persisting pain and numbness than open mesh repair were tested by follow‐up within a multicentre randomized clinical trial.
Journal ArticleDOI
Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli
Lino Becerra,Susie Morris,Shelly Bazes,Richard Gostic,Seth Sherman,Julie Gostic,Gautam Pendse,Eric A. Moulton,Steven J. Scrivani,David A. Keith,Boris Chizh,David Borsook +11 more
TL;DR: Sensory processing in patients with trigeminal neuropathic pain is associated with distinct activation patterns consistent with sensitization within and outside of the primary sensory pathway, which is consistent with the allodynia to brush and cold.
Journal ArticleDOI
Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5- HTTLPR) polymorphism, and relationship to anxiety-related personality traits.
Journal ArticleDOI
Heritability of symptoms in an experimental model of neuropathic pain.
Marshall Devor,Pnina Raber +1 more
TL;DR: The data suggest that autotomy is inherited as a single‐gene autosomal recessive trait in rats, consistent with simple mendelian inheritance of a single gene.