Transition from acute to chronic postsurgical pain: risk factors and protective factors
Joel Katz,Ze'ev Seltzer +1 more
TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.Abstract:
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...read more
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References
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Journal ArticleDOI
Possible impact of genetic differences on the development of neuropathic pain-like behaviors after unilateral sciatic nerve ischemic injury in rats
TL;DR: The results showed that normal sensitivity and the development of pain‐like response after partial nerve injury differ substantially among different strains of rats, supporting the emerging concept that genetic factors affect pain sensitivity under normal conditions and after nerve injury.
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TL;DR: There are now three models of neuropathic pain in the rat that are in widespread use: the chronic constriction injury, the partial sciatic ligation model, and the spinal nerve ligation models as mentioned in this paper.
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High dose alfentanil pre-empts pain after abdominal hysterectomy
Joel Katz,Michel Clairoux,Cormac Redahan,Brian P. Kavanagh,Sandra L Carroll,Hilary Nierenberg,Marla Jackson,Jane Beattie,Anna Taddio,Alan N. Sandler +9 more
TL;DR: It is concluded that intra‐operative high dose alfentanil anaesthetic pre‐empts post‐operative pain after abdominal hysterectomy, but the effects are small and of short duration.
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Interleukin-1β and Serotonin Transporter Gene Polymorphisms in Burning Mouth Syndrome Patients
André Luiz Sena Guimarães,Alessandra Rosa de Sá,Júnia Maria Netto Victória,Jeane de Fátima Correia-Silva,Marcus Vinicius Gomez,Ricardo Santiago Gomez +5 more
TL;DR: Evidence is shown that genetic polymorphisms associated with IL-1beta high production genotype are implicated on the pathogenesis of BMS, and the modulation of IL1beta production may be an interesting tool in BMS management.
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Functional serotonin 5–HTTLPR polymorphism is a risk factor for migraine with aura
Barbara Borroni,Cristina Brambilla,Paolo Liberini,Renata Rao,Silvana Archetti,Stefano Gipponi,G. Dalla Volta,Alessandro Padovani +7 more
TL;DR: The present work reports that the functional serotonin transporter gene promoter (5–HTTLPR) polymorphism is involved in migraine pathogenesis, and provides a further insight on the complex genotypephenotype relationship involved in MA pathogenesis.