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Open AccessJournal ArticleDOI

Transition from acute to chronic postsurgical pain: risk factors and protective factors

TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.
Abstract
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...

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Citations
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Journal ArticleDOI

Rates and risk factors for prolonged opioid use after major surgery: population based cohort study

TL;DR: Specific patient and surgical characteristics were associated with the development of prolonged postoperative use of opioids, and these findings can help better inform understanding about the long term risks of opioid treatment for acute postoperative pain.
Journal ArticleDOI

Poorly controlled postoperative pain: prevalence, consequences, and prevention

TL;DR: Several new opioids have been developed that modulate μ-receptor activity by selectively engaging intracellular pathways associated with analgesia and not those associated with adverse events, creating a wider therapeutic window than unselective conventional opioids.
Journal ArticleDOI

What we know about primary dysmenorrhea today: a critical review

TL;DR: The extensive multi-factorial impact of dysmenorrhea is demonstrated, evident even in phases of the menstrual cycle when women are not experiencing menstrual pain, illustrating that long-term differences in pain perception extend outside of the painful menstruation phase.
Journal ArticleDOI

Treatment of acute postoperative pain

TL;DR: This work examines the development of new analgesic agents and treatment modalities and regimens for acute postoperative pain, and investigates the use of specific analgesic techniques such as regional analgesia to improve patient outcomes.
References
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Journal ArticleDOI

Chronic pain and posttraumatic stress disorder: mutual maintenance?

TL;DR: It is concluded that chronic pain and PTSD are mutually maintaining conditions and that there are several pathways by which both disorders may be involved in the escalation of symptoms and distress following trauma.
Journal ArticleDOI

Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa.

TL;DR: The time course and degree of autotomy following various types of nerve injury in rats and mice is described and reasons are given to propose that autotomy is triggered by an abnormal afferent barrage generated in the cut end of the nerve.
Journal ArticleDOI

Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats

TL;DR: The dorsal root ganglion with its ongoing activity and mechanical sensitivity could be a source of pain producing impulses and could particularly contribute to pain in those conditions of peripheral nerve damage where pain persists after peripheral anaesthesia or where vertebral manipulation is painful.
Journal ArticleDOI

The prevention of postoperative pain.

Wall Pd
- 01 Jun 1988 - 
Journal ArticleDOI

Chronic pain after surgery

TL;DR: Predictive factors are reviewed and core risk factor and outcome domains for inclusion in future epidemiological studies investigating chronic pain after surgery are proposed to advance the field of CPSP research by striving for consensus among pain experts.
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