Transition from acute to chronic postsurgical pain: risk factors and protective factors
Joel Katz,Ze'ev Seltzer +1 more
TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.Abstract:
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...read more
Citations
More filters
Journal ArticleDOI
Rates and risk factors for prolonged opioid use after major surgery: population based cohort study
Hance Clarke,Neilesh Soneji,Neilesh Soneji,Dennis T. Ko,Dennis T. Ko,Lingsong Yun,Duminda N. Wijeysundera +6 more
TL;DR: Specific patient and surgical characteristics were associated with the development of prolonged postoperative use of opioids, and these findings can help better inform understanding about the long term risks of opioid treatment for acute postoperative pain.
Journal ArticleDOI
Poorly controlled postoperative pain: prevalence, consequences, and prevention
TL;DR: Several new opioids have been developed that modulate μ-receptor activity by selectively engaging intracellular pathways associated with analgesia and not those associated with adverse events, creating a wider therapeutic window than unselective conventional opioids.
Journal ArticleDOI
What we know about primary dysmenorrhea today: a critical review
TL;DR: The extensive multi-factorial impact of dysmenorrhea is demonstrated, evident even in phases of the menstrual cycle when women are not experiencing menstrual pain, illustrating that long-term differences in pain perception extend outside of the painful menstruation phase.
Journal ArticleDOI
Treatment of acute postoperative pain
TL;DR: This work examines the development of new analgesic agents and treatment modalities and regimens for acute postoperative pain, and investigates the use of specific analgesic techniques such as regional analgesia to improve patient outcomes.
References
More filters
Journal ArticleDOI
pain2: A neuropathic pain QTL identified on rat chromosome 2.
Jonathan Nissenbaum,Hagai Y. Shpigler,Anne Pisanté,Sonia delCanho,Anne Minert,Ze'ev Seltzer,Marshall Devor,Ariel Darvasi +7 more
TL;DR: This work based on rat selection lines HA and LA, which show a contrasting pain phenotype in response to nerve injury in the neuroma model of neuropathic pain, found a chronic pain‐associated QTL in the rat that was mapped to the 14–26 cM interval of chromosome 2, and is named pain2.
Journal ArticleDOI
Management of nerves during leg amputation--a neglected area in our understanding of the pathogenesis of phantom limb pain.
S. Rasmussen,H. Kehlet +1 more
TL;DR: This study investigates the clinical practice of nerve handling during leg amputation and recommends that the ischial nerve be ligated, despite the fact that the experimental literature uses nerve ligations to produce neuropathic pain.
Journal ArticleDOI
Chronic pain after sternotomy
TL;DR: This study reached the conclusion that chronic pain was more common after internal mammary (internal thoracic) artery grafting than saphenous vein grafting, and this finding does seem justified from the evidence.
Journal Article
Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion.
Simon Vaculin,Rokyta R +1 more
TL;DR: The results suggest the crucial role of anesthesia, especially that which involved NMDA receptors (ketamine), and the need of an additional factor to chronic deafferentation, formed either by activity of nociceptive pathways just before rhizotomy (nocICEptive stimulation preceding ketamine anesthesia) or by injury discharges (pentobarbital anesthesia).