Transition from acute to chronic postsurgical pain: risk factors and protective factors
Joel Katz,Ze'ev Seltzer +1 more
TLDR
It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.Abstract:
Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic pain. However, a rarely appreciated fact is that every chronic pain was once acute. Here, we argue that a focus on the transition from acute to chronic pain may reveal important cues that will help us to predict who will go on to develop chronic pain and who will not. Unlike other injuries, surgery presents a unique set of circumstances in which the precise timing of the physical insult and ensuing pain are known in advance. This provides an opportunity, before surgery, to identify the risk factors and protective factors that predict the course of recovery. In this paper, the epidemiology of chronic postsurgical pain...read more
Citations
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Pain in Cancer Survivors
Paul Glare,Pamela Stitzlein Davies,Esme Finlay,Amitabh Gulati,Dawn Lemanne,Natalie Moryl,Kevin C. Oeffinger,Judith A. Paice,Michael D. Stubblefield,Karen L. Syrjala +9 more
TL;DR: This article focuses on patients with a history of cancer who are beyond the acute diagnosis and treatment phase and on common treatment-related pain etiologies, reviewing the benefits and harms of the various pharmacologic and nonpharmacologic options for pain management in this setting.
Journal ArticleDOI
Persistent Postsurgical Pain: Pathophysiology and Preventative Pharmacologic Considerations.
TL;DR: Clinical investigations evaluating different preventative pharmacologic strategies that are routinely used by anesthesiologists in their daily clinical practices for preventing persistent postoperative pain are described.
Journal ArticleDOI
The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms
TL;DR: A need for a concerted, strategic effort toward integrating clinical epidemiology, basic science research, and current theory about pain mechanisms to hasten progress toward understanding, managing, and preventing persistent postsurgical pain is revealed.
Journal ArticleDOI
Pharmacotherapy for the prevention of chronic pain after surgery in adults
TL;DR: Meta-analysis suggested a modest but statistically significant reduction in the incidence of chronic pain after surgery following treatment with ketamine but not gabapentin or pregabalin, and available evidence does not support the efficacy of gabAPentin, pregABalin, non-steroidal anti-inflammatories, intravenous steroids, oral NMDA blockers or inhaled nitrous oxide for the prevention of chronic postoperative pain.
Journal ArticleDOI
Psychological, surgical, and sociodemographic predictors of pain outcomes after breast cancer surgery: a population-based cohort study.
Julie Bruce,Alison Thornton,Rachael Powell,Marie Johnston,Mary Wells,Steven D. Heys,Alastair M. Thompson,W. Cairns S. Smith,W Alastair Chambers,Neil W. Scott +9 more
TL;DR: Investigating preoperative sociodemographic and psychological factors, intraoperative clinical factors, and acute postoperative pain in a prospective cohort of 362 women undergoing surgery for primary breast cancer found multiple psychological factors and nerve division was associated with chronic pain at 4 and 9 months.
References
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Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms
Journal ArticleDOI
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis
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TL;DR: Here, a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain is developed, identifying distinct forms of Plasticity, which are term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.