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Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America.
Constance A. Benson,Jonathan E. Kaplan,Henry Masur,Alice Pau,King K. Holmes +4 more
- Vol. 53, pp 1-112
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TLDR
These guidelines are intended for clinicians and other health-care providers who care for HIV-infected adults and adolescents, including pregnant women, and include evidence-based guidelines for treatment of 28 OIs caused by protozoa, bacteria, fungi, and viruses.Abstract:
The National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, and CDC have developed guidelines for treatment of opportunistic infections (OIs) among adults and adolescents infected with human immunodeficiency virus (HIV). These guidelines are intended for clinicians and other health-care providers who care for HIV-infected adults and adolescents, including pregnant women; they complement companion guidelines for treatment of OIs among HIV-infected children and previously published guidelines for prevention of OIs in these populations. They include evidence-based guidelines for treatment of 28 OIs caused by protozoa, bacteria, fungi, and viruses, including certain OIs endemic in other parts of the world but that might be observed in patients in the United States. Each OI section includes information on epidemiology, clinical manifestations, diagnosis, treatment recommendations, monitoring and adverse events, management of treatment failure, prevention of recurrence, and special considerations in pregnancy. Tables address drugs and doses, drug toxicities, drug interactions, adjustment of drug doses in persons with reduced renal function, and data about use of drugs in pregnant women.read more
Citations
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Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies
Adam Trickey,Margaret T May,Jorg-Janne Vehreschild,Niels Obel,M. John Gill,M. John Gill,Heidi M. Crane,Christoph Boesecke,Sophie Patterson,Sophie Grabar,Charles Cazanave,Matthias Cavassini,Leah Shepherd,Antonella d'Arminio Monforte,Ard van Sighem,Michael S. Saag,Fiona C Lampe,Vicky Hernando,Marta Montero,Robert Zangerle,Amy C. Justice,Timothy R. Sterling,Timothy R. Sterling,Suzanne M Ingle,Jonathan A C Sterne +24 more
TL;DR: Even in the late ART era, survival during the first 3 years of ART continues to improve, which probably reflects transition to less toxic antiretroviral drugs, improved adherence, prophylactic measures, and management of comorbidity.
Journal Article
Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents
Jonathan E. Kaplan,Constance A. Benson,King K. Holmes,John T. Brooks,Alice Pau PharmD,Henry Masur +5 more
TL;DR: This report updates and combines earlier versions of guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents and adds malaria to the list of OIs that might be acquired during international travel.
Journal ArticleDOI
Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
Graeme Meintjes,Robert J. Wilkinson,Chelsea Morroni,Dominique J. Pepper,Kevin Rebe,Molebogeng X Rangaka,Tolu Oni,Gary Maartens +7 more
TL;DR: Prednisone reduced the need for hospitalization and therapeutic procedures and hastened improvements in symptoms, performance, and quality of life while investigating for drug-resistant tuberculosis and other causes for deterioration before administering glucocorticoids.
Journal ArticleDOI
The HBV drug entecavir - effects on HIV-1 replication and resistance.
Moira A. McMahon,Benjamin L. Jilek,Timothy P. Brennan,Lin Shen,Yan Zhou,Megan Wind-Rotolo,Sifei Xing,Shridhar Bhat,Braden R. Hale,Robert Hegarty,Curtis R. Chong,Jun O. Liu,Robert F. Siliciano,Chloe L. Thio +13 more
TL;DR: Caution is needed with the use of entecavir in persons with HIV-1 and HBV coinfection who are not receiving fully suppressive antiretroviral regimens, and in vitro experiments showed that M184V confers resistance to entecvir.
References
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