Journal ArticleDOI
Tuberculosis: Current Status, Diagnosis, Treatment and Development of Novel Vaccines.
TLDR
The available treatments and new approaches to develop potent vaccines for the treatment of TB are focused on.Abstract:
Tuberculosis (TB) is an infectious disease that mainly affects the lungs and spreads to other organs of the body through the haematogenous route. It is one of the ten major causes of mortality worldwide. India has the highest incidence of new- and multidrug-resistant (MDR) - TB cases in the world. Bacille Calmette-Guerin (BCG) is the vaccine commonly available against TB. BCG does offer some protection against serious forms of TB in childhood but its protective effect wanes with age. Many new innovative strategies are being trailed for the development of effective and potent vaccines like mucosal- and epitope-based vaccines, which may replace BCG or boost BCG responses. The use of nanotechnology for diagnosis and treatment of TB is also in the pipeline along with many other vaccines, which are under clinical trials. Further, in-silico models were developed for finding new drug targets and designing drugs against Mycobacterium tuberculosis (Mtb). These models offer the benefit of computational experiments which are easy, inexpensive and give quick results. This review will focus on the available treatments and new approaches to develop potent vaccines for the treatment of TB.read more
Citations
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The role of innate lymphoid cells in response to microbes at mucosal surfaces.
TL;DR: The role of ILCs in response to the microbiota and to microbial infections of the lung and intestine is reviewed, as they can both influence and in turn be influenced by the microbiome.
Journal ArticleDOI
An Overview of the Development of New Vaccines for Tuberculosis.
TL;DR: Current vaccination strategies are discussed, directions for the possible routes towards the development of new TB vaccines are provided, and recent findings are highlighted.
Journal ArticleDOI
Status and challenges for tuberculosis control in India – Stakeholders' perspective
TL;DR: There is a long way to go to achieve significant reduction in high incidence and prevalence of TB in India, factors like lack of awareness and resources, poor infrastructure, increasing drug resistant cases, poor notification and overall negligence are the major challenges.
Journal ArticleDOI
Pulmonary Protein Oxidation and Oxidative Stress Modulation by Lemna minor L. in Progressive Bleomycin-Induced Idiopathic Pulmonary Fibrosis
TL;DR: L. minor improves the preventive effect/defense response in specific pulmonary protein oxidation, lipid peroxidation, ROS identifications, and cytokine modulation by BLM-induced chronic inflammations, and could be a good antioxidant, anti-inflammatory, and anti-fibrotic alternative or IPF prevention involved in their pathogenesis.
Journal ArticleDOI
Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes
Irina Tsymala,Magdalini Nigritinou,Bleranda Zeka,Rouven Schulz,Felix Niederschick,Mia Matković,Isabel J. Bauer,Michael Szalay,Kathrin Schanda,Magdalena Lerch,Tatsuro Misu,Kazuo Fujihara,Jeffrey Bennett,Charlotte Dahle,Florence Pache,Paulus S. Rommer,Fritz Leutmezer,Zsolt Illes,Maria Isabel Leite,Jacqueline Palace,Petra Scholze,Markus Reindl,Hans Lassmann,Monika Bradl +23 more
TL;DR: In this paper, the authors identified peptides which mimic the conformational AQP4 epitopes recognized by pathogenic antibodies of neuromyelitis optica spectrum disorders (NMOSD) patients.
References
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Journal ArticleDOI
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Evelina Tacconelli,Elena Carrara,Alessia Savoldi,Stéphan Juergen Harbarth,Marc Mendelson,Dominique L Monnet,Céline Pulcini,Gunnar Kahlmeter,Jan Kluytmans,Yehuda Carmeli,Marc Ouellette,Kevin Outterson,Jean B. Patel,Marco Cavaleri,Edward Cox,Christopher R. Houchens,M Lindsay Grayson,Paul Hansen,Nalini Singh,Ursula Theuretzbacher,Nicola Magrini,Aaron O. Aboderin,Seif Al-Abri,Nordiah Awang Jalil,Nur Benzonana,Sanjay Bhattacharya,Adrian Brink,Francesco Robert Burkert,Otto Cars,Giuseppe Cornaglia,Oliver J. Dyar,Alexander W. Friedrich,Ana Cristina Gales,Sumanth Gandra,Christian G. Giske,Debra A. Goff,Herman Goossens,Thomas Gottlieb,Manuel Guzman Blanco,Waleria Hryniewicz,Deepthi Kattula,Timothy Jinks,Souha S. Kanj,Lawrence Kerr,Marie-Paule Kieny,Yang Soo Kim,Roman S. Kozlov,Jaime Labarca,Ramanan Laxminarayan,Karin Leder,Leonard Leibovici,Gabriel Levy-Hara,Jasper Littman,Surbhi Malhotra-Kumar,Vikas Manchanda,Lorenzo Moja,Babacar Ndoye,Angelo Pan,David L. Paterson,Mical Paul,Haibo Qiu,Pilar Ramon-Pardo,Jesús Rodríguez-Baño,Maurizio Sanguinetti,Sharmila Sengupta,Mike Sharland,Massinissa Si-Mehand,Lynn L. Silver,Wonkeung Song,Martin Steinbakk,Jens Thomsen,Guy E. Thwaites,Jos W. M. van der Meer,Nguyen Van Kinh,Silvio Vega,Maria Virginia Villegas,Agnes Wechsler-Fördös,Heiman F. L. Wertheim,Evelyn Wesangula,Neil Woodford,Fidan O Yilmaz,Anna Zorzet +81 more
TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.
Journal ArticleDOI
The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling.
Rein M G J Houben,Peter J. Dodd +1 more
TL;DR: Investment in new tools to improve diagnosis and treatment of those with LTBI at risk of progressing to disease is urgently needed to address this latent reservoir if the 2050 target of eliminating TB is to be reached.
Journal ArticleDOI
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Troy D. Querec,Rama Akondy,Eva K. Lee,Weiping Cao,Helder I. Nakaya,Dirk E. Teuwen,Ali A. Pirani,Kim M. Gernert,Jiusheng Deng,Bruz Marzolf,Kathleen A. Kennedy,Haiyan Wu,Soumaya Bennouna,Herold Oluoch,Joseph I. Miller,Ricardo Z. N. Vêncio,Mark J. Mulligan,Alan Aderem,Rafi Ahmed,Bali Pulendran,Bali Pulendran +20 more
TL;DR: This article used a system biology approach to identify early gene signatures that predicted immune responses in humans vaccinated with the yellow fever vaccine YF-17D, with up to 90% accuracy in an independent, blinded trial.
Journal Article
The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis : meta-analyses of the published literature
Graham A. Colditz,Catherine S. Berkey,Frederick Mosteller,Timothy F. Brewer,Mary E. Wilson,Elisabeth Burdick,Harvey V. Fineberg +6 more
TL;DR: BCG vaccination of newborns and infants significantly reduces the risk of tuberculosis--by over 50%, on average, suggesting that BCG efficacy may persist through 10 years after infant vaccination.
Journal ArticleDOI
Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis
Martina Sester,Giovanni Sotgiu,Christoph Lange,Claudia Giehl,Enrico Girardi,Giovanni Battista Migliori,Aik Bossink,Keertan Dheda,Roland Diel,José Domínguez,Marc Lipman,Johannes Nemeth,Pernille Ravn,Stefan Winkler,Emma Huitric,Andreas Sandgren,Davide Manissero +16 more
TL;DR: Although the diagnostic sensitivities of both IGRAs were higher than that of tuberculin skin tests, it was still not high enough to use as a rule out test for TB.