Update on adenovirus and its vectors.
Reads0
Chats0
TLDR
The paper was originally published in Journal of General Virology (2000), 81, 2573–2604 and has been republished here with edits since then.Abstract:
IP: 54.70.40.11 On: Thu, 03 Jan 2019 17:11:19 Journal of General Virology (2000), 81, 2573–2604. Printed in Great Britain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .read more
Citations
More filters
Journal ArticleDOI
Foot-and-Mouth Disease
Marvin J. Grubman,Barry Baxt +1 more
TL;DR: The reemergence of FMD in developed countries that had been disease free for many years is described and the effect that this has had on disease control strategies is described.
Journal ArticleDOI
Polyethylenimine-based non-viral gene delivery systems.
TL;DR: Insight is given into strategies developed for PEI-based non-viral vectors to overcome intracellular obstacles, including the improvement of methods for polyplex preparation and the incorporation of endosomolytic agents or nuclear localization signals.
Journal ArticleDOI
Genetic content and evolution of adenoviruses.
TL;DR: The antiquity of the pre-vertebrate lineages that ultimately gave rise to the Adenoviridae is illustrated by morphological similarities between adenoviruses and bacteriophages, and by use of a protein-primed DNA replication strategy by adenOViruses, certain bacteria and bacter iophage, and linear plasmids of fungi and plants.
Journal ArticleDOI
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
April Goehring,Chia Hsueh Lee,Kevin H. Wang,Jennifer J. Carlisle Michel,Derek P. Claxton,Isabelle Baconguis,Thorsten Althoff,Suzanne Fischer,K. Christopher Garcia,Eric Gouaux +9 more
TL;DR: In this paper, the plasmid Eric Gouaux (pEG) BacMam, a vector optimized for use in screening assays, as well as for efficient production of baculovirus and robust expression of the target protein.
Journal ArticleDOI
Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo.
TL;DR: The findings further clarify the early immune response against replication-deficient adenoviral vectors and suggest a strategy to preventadenovirus-mediated inflammation and tissue injury by interfering with chemokine or neutrophil function.
References
More filters
Journal ArticleDOI
Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5
TL;DR: Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA, and the transformed cells exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen.
PatentDOI
A simplified system for generating recombinant adenoviruses
TL;DR: In this paper, a recombinant adenoviral plasmid is generated with a minimum of enzymatic manipulations, employing homologous recombination in bacteria rather than in eucaryotic cells.
Journal ArticleDOI
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI
Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group.
Ravinder N. Maini,E W St Clair,F. C. Breedveld,Daniel E. Furst,Joachim R. Kalden,Michael H. Weisman,Josef S. Smolen,Paul Emery,G Harriman,Marc Feldmann,Peter E. Lipsky +10 more
TL;DR: Infliximab was well-tolerated; withdrawals for adverse events as well as the occurrence of serious adverse events or serious infections did not exceed those in the placebo group.
Journal ArticleDOI
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
TL;DR: In this article, the vitronectin-binding integrins α v β 3 and β 5 promote viral infection in a novel way since antibodies against these receptors or soluble penton base block virus internalization without affecting attachment.