Journal ArticleDOI
Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A
Christian A. Ruge,Julian Kirch,Olga Cañadas,Marc Schneider,Jesús Pérez-Gil,Ulrich F. Schaefer,Cristina Casals,Claus-Michael Lehr +7 more
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TLDR
Evidence is provided that after inhalation of nanoparticles, a different protein coating and thus different biological behavior may result compared to direct administration to the bloodstream, which is significant for nano-toxicology.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2011-12-01. It has received 127 citations till now. The article focuses on the topics: Surfactant protein A & Nanotoxicology.read more
Citations
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Journal ArticleDOI
Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
TL;DR: Current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake are summarized to help generate bio-compatible nanomaterials with controlled surface characteristics in a biological environment.
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Upconverting nanoparticles: assessing the toxicity
TL;DR: The underlying mechanisms of nanot toxicity are surveyed and an overview on the nanotoxicity of lanthanide doped nanoparticles and of upconverting nanoparticles is provided.
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The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.
Claudia Corbo,Roberto Molinaro,Alessandro Parodi,Naama E. Toledano Furman,Francesco Salvatore,Ennio Tasciotti +5 more
TL;DR: A survey of recent findings on the NP-PC interactions is provided and how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers is discussed.
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Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance
TL;DR: The lung, liver, and kidney are the major distribution sites and target organs for NMs exposure, and the clearance patterns of NMs in these organs are critical for understanding the in vivo fate of N Ms.
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Structure-function relationships in pulmonary surfactant membranes: From biophysics to therapy
TL;DR: The present review summarises current models on the molecular mechanisms of surfactant function, with particular emphasis in its biophysical properties to stabilise the lungs and the molecular alterations connecting impaired Surfactant with diseased organs.
References
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Journal ArticleDOI
Protein-nanoparticle interactions
Iseult Lynch,Kenneth A. Dawson +1 more
TL;DR: It is shown here that highly selective protein adsorption, added to the fact that particles can reach subcellular locations, results in significant new potential impacts for nanoparticles on protein interactions and cellular behavior.
Journal ArticleDOI
Pulmonary surfactant: functions and molecular composition
TL;DR: It is concluded that, in spite of much effort, the authors still do not understand the basic molecular mechanisms underlying surfactant's rapid adsorption to the air-water interface.
Journal ArticleDOI
Deposition and biokinetics of inhaled nanoparticles
TL;DR: The presented approach ranges from inhaled particle deposition probability and retention in the respiratory tract to biokinetics and clearance of particles out of the respiratory tracts, and emphasizes the importance for quantitative analyses and the use of particle doses derived from real world exposures.
Journal ArticleDOI
Nanoparticles for drug delivery to the lungs.
TL;DR: Novel methods formulating nanoparticles into the form of micron-scale dry powders have been developed, which exhibit improved handling and delivery, while releasing nanoparticles upon deposition in the lungs.
BookDOI
Protein-Nanoparticle Interactions
TL;DR: This chapter reviews and discusses the major biomedical applications of nanoparticles and indicates that nanotechnology will have substantial economic impacts by encouraging productivity and competitiveness, converging different disciplines of science and technologies, and stimulating education and human development.