Vertex models: from cell mechanics to tissue morphogenesis
Reads0
Chats0
TLDR
Various formulations of vertex models that have been proposed for describing tissues in two and three dimensions are reviewed, a generic formulation using a virtual work differential is discussed, and applications of vertices to biological morphogenetic processes are reviewed.Abstract:
Tissue morphogenesis requires the collective, coordinated motion and deformation of a large number of cells. Vertex model simulations for tissue mechanics have been developed to bridge the scales between force generation at the cellular level and tissue deformation and flows. We review here various formulations of vertex models that have been proposed for describing tissues in two and three dimensions. We discuss a generic formulation using a virtual work differential, and we review applications of vertex models to biological morphogenetic processes. We also highlight recent efforts to obtain continuum theories of tissue mechanics, which are effective, coarse-grained descriptions of vertex models.This article is part of the themed issue 'Systems morphodynamics: understanding the development of tissue hardware'.read more
Citations
More filters
Journal Article
Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary
Katharina P. Landsberg,Reza Farhadifar,Jonas Ranft,Daiki Umetsu,Thomas J. Widmann,Thomas Bittig,Amani Said,Frank Jülicher,Christian Dahmann +8 more
TL;DR: This work quantitatively analyzed cell morphology and the response to the laser ablation of cell bonds in the vicinity of the anteroposterior compartment boundary in developing Drosophila wings and provides a physical mechanism in which the local increase in Myosin II-dependent cell bond tension directs cell sorting at compartment boundaries.
Journal ArticleDOI
A Review of Cell-Based Computational Modeling in Cancer Biology.
TL;DR: This review introduces the broad range of techniques available for cell-based computational modeling and illustrates these methods with examples drawn from cancer hypoxia, angiogenesis, invasion, stem cells, and immunosurveillance.
Journal ArticleDOI
The 2020 motile active matter roadmap
Gerhard Gompper,Roland G. Winkler,Thomas Speck,Alexandre Solon,Cesare Nardini,Fernando Peruani,Hartmut Löwen,Ramin Golestanian,Ramin Golestanian,U. Benjamin Kaupp,Luis Alvarez,Thomas Kiørboe,Eric Lauga,Wilson C. K. Poon,Antonio DeSimone,Santiago Muiños-Landin,Alexander Fischer,Nicola Andreas Söker,Frank Cichos,Raymond Kapral,Pierre Gaspard,Marisol Ripoll,Francesc Sagués,Amin Doostmohammadi,Julia M. Yeomans,Igor S. Aranson,Clemens Bechinger,Holger Stark,Charlotte K. Hemelrijk,François Nédélec,Trinish Sarkar,Thibault Aryaksama,Mathilde Lacroix,Guillaume Duclos,Victor Yashunsky,Pascal Silberzan,Marino Arroyo,Sohan Kale +37 more
TL;DR: The 2019 motile active matter roadmap of Journal of Physics: Condensed Matter addresses the current state of the art of the field and provides guidance for both students as well as established scientists in their efforts to advance this fascinating area as discussed by the authors.
Journal ArticleDOI
Active superelasticity in three-dimensional epithelia of controlled shape
Ernest Latorre,Sohan Kale,Laura Casares,Manuel Gomez-Gonzalez,Marina Uroz,Léo Valon,Roshna V. Nair,Elena Garreta,Nuria Montserrat,Aránzazu del Campo,Aránzazu del Campo,Benoit Ladoux,Benoit Ladoux,Marino Arroyo,Xavier Trepat +14 more
TL;DR: This study reveals a type of mechanical behaviour that enables epithelial sheets to sustain extreme stretching under constant tension, and shows that in epithelial cells this instability is triggered by a stretch-induced dilution of the actin cortex, and is rescued by the intermediate filament network.
Journal Article
Correction for The role of fluctuations and stress on the effective viscosity of cell aggregates
Philippe Marmottant,Abbas Mgharbel,Jos Käfer,Benjamin Audren,Jean-Paul Rieu,Jean-Claude Vial,Boudewijn van der Sanden,Athanasius F. M. Marée,François Graner,Hélène Delanoë-Ayari +9 more
TL;DR: This work develops a mechanical model of aggregates based on their cellular structure and discusses the deviations from liquid behavior, the possible overestimation of surface tension in parallel-plate compression measurements, and the role of measurement duration.
References
More filters
Journal ArticleDOI
Hydrodynamics of soft active matter
M. C. Marchetti,Jean-François Joanny,Jean-François Joanny,Sriram Ramaswamy,Sriram Ramaswamy,Tanniemola B. Liverpool,Jacques Prost,Jacques Prost,Madan Rao,R. Aditi Simha,R. Aditi Simha +10 more
TL;DR: This review summarizes theoretical progress in the field of active matter, placing it in the context of recent experiments, and highlights the experimental relevance of various semimicroscopic derivations of the continuum theory for describing bacterial swarms and suspensions, the cytoskeleton of living cells, and vibrated granular material.
Book
Mechanics of Motor Proteins and the Cytoskeleton
Jonathon Howard,RL Clark +1 more
TL;DR: The Motility Models: From Crossbridges to Motion chapter describes the building blocks of the Cytoskeleton and some of the mechanisms used in its manufacture are described.
Journal ArticleDOI
Self-organizing optic-cup morphogenesis in three-dimensional culture
Mototsugu Eiraku,Nozomu Takata,Hiroki Ishibashi,Masako Kawada,Eriko Sakakura,Satoru Okuda,Kiyotoshi Sekiguchi,Taiji Adachi,Yoshiki Sasai +8 more
TL;DR: The dynamic, autonomous formation of the optic cup (retinal primordium) structure from a three-dimensional culture of mouse embryonic stem cell aggregates is reported, demonstrating that optic-cup morphogenesis in this simple cell culture depends on an intrinsic self-organizing program involving stepwise and domain-specific regulation of local epithelial properties.
Journal ArticleDOI
Simulation of biological cell sorting using a two-dimensional extended Potts model.
François Graner,James A. Glazier +1 more
TL;DR: This work simulates the sorting of a mixture of two types of biological cells using a modified version of the large-Q Potts model with differential adhesivity and finds long-distance cell movement leading to sorting with a logarithmic increase in the length scale of homogeneous clusters.
Journal ArticleDOI
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis.
TL;DR: A range of developmental phenomena can be explained by the regulation of cell surface tension, and the framework that emerges from diverse disciplines such as cell biology, physics and developmental biology points to adhesion and cortical actin networks as regulators ofcell surface mechanics.