White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three.
Barbara B. Bendlin,Michele E. Fitzgerald,Michele L. Ries,Guofan Xu,Erik K. Kastman,Brent W. Thiel,Howard A. Rowley,Mariana Lazar,Andrew L. Alexander,Sterling C. Johnson +9 more
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TLDR
The results suggest that age-related white matter alterations underlie age- related declines in cognitive function and the complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation.Abstract:
Structural brain change and concomitant cognitive decline are the seemingly unavoidable escorts of aging. Despite accumulating studies detailing the effects of age on the brain and cognition, the relationship between white matter features and cognitive function in aging have only recently received attention and remain incompletely understood. White matter microstructure can be measured with diffusion tensor imaging (DTI), but whether DTI can provide unique information on brain aging that is not explained by white matter volume is not known. In the current study, the relationship between white matter microstructure, age, and neuropsychological function was assessed using DTI in a statistical framework that employed white matter volume as a voxel-wise covariate in a sample of 120 healthy adults across a broad age range (18-83). Memory function and executive function were modestly correlated with the DTI measures while processing speed showed the greatest extent of correlation. The results suggest that age-related white matter alterations underlie age-related declines in cognitive function. Mean diffusivity and fractional anisotropy in several white matter brain regions exhibited a nonlinear relationship with age, while white matter volume showed a primarily linear relationship with age. The complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation.read more
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Diffusion tensor imaging of white matter tract evolution over the lifespan
Catherine Lebel,Michael S. Gee,Richard Camicioli,Marguerite Wieler,W.R. Wayne Martin,Christian Beaulieu +5 more
TL;DR: Clear age-related microstructural changes throughout the brain white matter are demonstrated, and normative data is provided that will be useful for studying white matter development in a variety of diseases and abnormal conditions.
Journal ArticleDOI
Neuroanatomical substrates of age-related cognitive decline.
TL;DR: The evidence that aspects of brain structure are neuroanatomical substrates of age-related cognitive decline is weak, and several suggestions concerning measurement and methodology are included that may lead to stronger conclusions in the future.
Journal ArticleDOI
Disconnected aging: cerebral white matter integrity and age-related differences in cognition.
Ilana J. Bennett,David J. Madden +1 more
TL;DR: In this article, a review summarizes results of previous diffusion tensor imaging aging research with the aim of identifying consistent patterns of age-related differences in white matter integrity, and of relationships between measures of white-matter integrity and behavioral performance as a function of adult age.
Journal ArticleDOI
Partial volume effect as a hidden covariate in DTI analyses
TL;DR: Testing the hypothesis that these PVE-related covariates modulate DTI metrics depending on the shape of a bundle indicate that the estimated bundle-specific mean values of diffusion metrics, including the frequently used fractional anisotropy and mean diffusivity, were indeed modulated by fiber bundle thickness, orientation, and curvature.
Journal ArticleDOI
Cognitive Processing Speed in Older Adults: Relationship with White Matter Integrity
Geoffrey A. Kerchner,Caroline A. Racine,Sandra Hale,Reva Wilheim,Victor Laluz,Bruce L. Miller,Joel H. Kramer +6 more
TL;DR: As expected, reaction time slowed significantly with age, and loss of white matter integrity mediated the relationship between age and cognitive processing speed in a statistical mediation analysis.
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