Journal ArticleDOI
Withania Somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
Muskan Gupta,Gurcharan Kaur +1 more
TLDR
This study provides first ever preclinical evidence and scientific validation that ASH-WEX exhibits the anti-neuroinflammatory potential against systemic LPS-induced neuroinflammation and ameliorates associated behavioral abnormalities.Abstract:
Reactive gliosis, microgliosis, and subsequent secretion of various inflammatory mediators like cytokines, proteases, reactive oxygen, and nitrogen species are the suggested key players associated with systemic inflammation-driven neuroinflammation and cognitive impairments in various neurological disorders. Conventionally, non-steroidal anti-inflammatory drugs are prescribed to suppress inflammation but due to their adverse effects, their usage is not well accepted. Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. In Ayurveda, Ashwagandha (Withania somnifera) is well known for its immunomodulatory properties. The current study is an extension of our previous report on in vitro model system and was aimed to investigate anti-neuroinflammatory potential of water extract from the Ashwagandha leaves (ASH-WEX) against systemic LPS-induced neuroinflammation and associated behavioral impairments using in vivo rat model system. Oral feeding of ASH-WEX for 8 weeks significantly ameliorated the anxiety-like behavior as evident from Elevated plus maze test. Suppression of reactive gliosis, inflammatory cytokines production like TNF-α, IL-1β, IL-6, and expression of nitro-oxidative stress enzymes like iNOS, COX2, NOX2 etc were observed in ASH-WEX-treated animals. NFκB, P38, and JNK MAPKs pathways analysis showed their involvement in inflammation suppression which was further confirmed by inhibitor studies. The current study provides first ever preclinical evidence and scientific validation that ASH-WEX exhibits the anti-neuroinflammatory potential against systemic LPS-induced neuroinflammation and ameliorates associated behavioral abnormalities. Aqueous extract from Ashwagandha leaves and its active phytochemicals may prove to be promising candidates to prevent neuroinflammation associated with various neuropathologies.read more
Citations
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Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.
TL;DR: Melatonin is an adaptation hormone playing an important role in regulation of homeostasis in organisms under stress, and for the first time is reported that the molecular mechanism of actions of melatonin and plant adaptogens are alike.
Journal ArticleDOI
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects.
Subhabrata Paul,Shreya Chakraborty,Uttpal Anand,Swarnali Dey,Samapika Nandy,Mimosa Ghorai,Suchismita Chatterjee Saha,Manoj Patil,Ramesh Kandimalla,Jarosław Proćków,Abhijit Dey +10 more
TL;DR: In this article, a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents are presented.
Journal ArticleDOI
Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management
Akash Saggam,Kirti Limgaokar,Swapnil P. Borse,Preeti Chavan-Gautam,Santosh Dixit,Girish Tillu,Bhushan Patwardhan +6 more
TL;DR: In this article, the authors presented a research synthesis of in silico, in vitro, in vivo, and clinical studies on Withania somnifera (L.) Dunal (WS) and discussed its potential for prophylaxis and management of COVID-19.
Journal ArticleDOI
Herbo-mineral formulation 'Ashwashila' attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model.
Acharya Balkrishna,Sachin Shridhar Sakat,Kheemraj Joshi,Sandeep Paudel,Deepika Joshi,Kamal Joshi,Ravikant Ranjan,Abhishek Gupta,Kunal Bhattacharya,Anurag Varshney +9 more
TL;DR: Pre-clinical efficacy of Ashwashila (ASHW) is shown in reducing RA associated symptoms by controlling inflammation and it is suggested as a potential therapeutic candidate for rheumatoid arthritis.
Journal ArticleDOI
Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation.
Muskan Gupta,Gurcharan Kaur +1 more
TL;DR: This extensive study provides first ever pre-clinical evidence that ASH-WEX can be used as a promising natural therapeutic remedial for the prevention of neurodegeneration and cognitive impairments associated with peripheral inflammation and neuroinflammation.
References
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