Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling
Olivera Stojadinovic,Tongyu C. Wikramanayake,Alexandra C. Villasante Fricke,Natalie C. Yin,Liang Liang,Eleanor Hinde,Julia Escandon,Marjana Tomic-Canic,Marjana Tomic-Canic,David M. Ansell,Ralf Paus,Ralf Paus,Joaquin J. Jimenez +12 more
Reads0
Chats0
TLDR
It is shown that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage, and it is concluded that wound healing switches the cutaneous cytokine milieu to an IL-1β-dominated state thus retarding HF growth progression and rendering the HFs resistant to chemotherapy agents.About:
This article is published in Heliyon.The article was published on 2017-05-01 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Hair cycle & Wound healing.read more
Citations
More filters
Journal ArticleDOI
Computational Drug Discovery in Chemotherapy-induced Alopecia via Text Mining and Biomedical Databases.
TL;DR: Gene enrichment analysis and protein-protein interaction analysis yielded 19 genes potentially targetable by a total of 29 drugs that could possibly be formulated for topical application in Chemotherapy-induced alopecia.
Journal ArticleDOI
The Role of Platelet-Rich Plasma in the Prevention of Chemotherapy-Induced Alopecia.
TL;DR: Chemotherapy-induced alopecia (CIA) occurs with various chemotherapeutic agents, but most prominent are alkylating agents (cyclophosphamide), antitumor antibiotics, antimicrotubule agents, and topoisomerase inhibitors (etoposide).
Journal ArticleDOI
Mild oxidative stress protects against chemotherapy-induced hair loss
Yusheng Zhang,Joaquin J. Jimenez +1 more
TL;DR: In this paper, a proof-of-concept treatment of using subcutaneous hydrogen peroxide and cumene hydroperoxide injections to provide total protection from hair loss against multiple classes of chemotherapy.
References
More filters
Journal ArticleDOI
Growth factors and cytokines in wound healing.
TL;DR: A review of the specific roles of these growth factors and cytokines during wound healing can be found in this article, where patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.
Journal ArticleDOI
Controls of hair follicle cycling.
Kurt S. Stenn,Ralf Paus +1 more
TL;DR: This review has used Chase as the model and tried to put the adult hair follicle growth cycle in perspective, and hopes that this work will serve as an introduction to basic biologists who are looking for a defined biological system that illustrates many of the challenges of modern biology.
Journal ArticleDOI
A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages.
Sven Müller-Röver,Bori Handjiski,Carina van der Veen,Stefan B. Eichmüller,Kerstin Foitzik,Ian A. McKay,Kurt S. Stenn,Ralf Paus +7 more
TL;DR: This guide should become a useful tool when screening new mouse mutants or mice treated with pharmaceuticals for discrete morphologic abnormalities of hair follicle cycling in a highly reproducible, easily applicable, and quantifiable manner.
Journal ArticleDOI
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis.
TL;DR: It is shown that ablation of bulge cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kinase leads to complete loss of hair follicles but survival of the epidermis, indicating that bulge stem cells respond rapidly to epidermal wounding by generating short-lived 'transient amplifying' cells responsible for acute wound repair.
Journal ArticleDOI
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
TL;DR: It is shown that, after wounding, hair follicles form de novo in genetically normal adult mice, and these remarkable regenerative capabilities of the adult support the notion that wounding induces an embryonic phenotype in skin, and that this provides a window for manipulation of hair follicle neogenesis by Wnt proteins.