Showing papers on "Perspective (graphical) published in 2018"

A Survey of Methods for Explaining Black Box Models

Abstract: In recent years, many accurate decision support systems have been constructed as black boxes, that is as systems that hide their internal logic to the user. This lack of explanation constitutes both a practical and an ethical issue. The literature reports many approaches aimed at overcoming this crucial weakness, sometimes at the cost of sacrificing accuracy for interpretability. The applications in which black box decision systems can be used are various, and each approach is typically developed to provide a solution for a specific problem and, as a consequence, it explicitly or implicitly delineates its own definition of interpretability and explanation. The aim of this article is to provide a classification of the main problems addressed in the literature with respect to the notion of explanation and the type of black box system. Given a problem definition, a black box type, and a desired explanation, this survey should help the researcher to find the proposals more useful for his own work. The proposed classification of approaches to open black box models should also be useful for putting the many research open questions in perspective.

Prefrontal cortex as a meta-reinforcement learning system

Abstract: Over the past 20 years, neuroscience research on reward-based learning has converged on a canonical model, under which the neurotransmitter dopamine ‘stamps in’ associations between situations, actions and rewards by modulating the strength of synaptic connections between neurons. However, a growing number of recent findings have placed this standard model under strain. We now draw on recent advances in artificial intelligence to introduce a new theory of reward-based learning. Here, the dopamine system trains another part of the brain, the prefrontal cortex, to operate as its own free-standing learning system. This new perspective accommodates the findings that motivated the standard model, but also deals gracefully with a wider range of observations, providing a fresh foundation for future research.

Cerebral small vessel disease: from a focal to a global perspective

Abstract: Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity among patients with similar degrees of SVD on brain imaging. Here, we provide a new framework based on new advances in structural and functional neuroimaging that aims to explain the remarkable clinical variation in SVD. First, we discuss the heterogeneous pathology present in SVD lesions despite an identical appearance on imaging and the perilesional and remote effects of these lesions. We review effects of SVD on structural and functional connectivity in the brain, and we discuss how network disruption by SVD can lead to clinical deficits. We address reserve and compensatory mechanisms in SVD and discuss the part played by other age-related pathologies. Finally, we conclude that SVD should be considered a global rather than a focal disease, as the classically recognized focal lesions affect remote brain structures and structural and functional network connections. The large variability in clinical symptoms among patients with SVD can probably be understood by taking into account the heterogeneity of SVD lesions, the effects of SVD beyond the focal lesions, the contribution of neurodegenerative pathologies other than SVD, and the interaction with reserve mechanisms and compensatory mechanisms.

From Classification to Causality: Advancing Understanding of Mechanisms of Change in Implementation Science

Abstract: Background: The science of implementation has offered little toward understanding how different implementation strategies work. To improve outcomes of implementation efforts, the field needs precise, testable theories that describe the causal pathways through which implementation strategies function. In this perspective piece, we describe a four-step approach to developing causal pathway models for implementation strategies. Building Causal Models: First, it is important to ensure that implementation strategies are appropriately specified. Some strategies in published compilations are well-defined but may not be specified in terms of its core component that can have a reliable and measureable impact. Second, linkages between strategies and mechanisms need to be generated. Existing compilations do not offer mechanisms by which strategies act, or the processes or events through which an implementation strategy operates to affect desired implementation outcomes. Third, it is critical to identify proximal and distal outcomes the strategy is theorized to impact, with the former being direct, measurable products of the strategy and the latter being one of eight implementation outcomes (1). Finally, articulating effect modifiers, like preconditions and moderators, allow for an understanding of where, when, and why strategies have an effect on outcomes of interest. Future Directions: We argue for greater precision in use of terms for factors implicated in implementation processes; development of guidelines for selecting research design and study plans that account for practical constructs and allow for the study of mechanisms; psychometrically strong and pragmatic measures of mechanisms; and more robust curation of evidence for knowledge transfer and use.

Growing a social brain.

Abstract: It has long been assumed that social animals, such as humans, are born with a brain system that has evolved to support social affiliation. However, the evidence does not necessarily support this assumption. Alternatively, social animals can be defined as those who cannot survive alone and rely on members from their group to regulate their ongoing physiology (or allostasis). The rather simple evolutionary constraint of social dependency for survival can be sufficient to make the social environment vitally salient, and to provide the ultimate driving force for socially crafted brain development and learning. In this Perspective, we propose a framework for sociality and specify a set of hypotheses on the mechanisms of social development and underlying neural systems. The theoretical shift proposed here implies that profound human characteristics, including but not limited to sociality, are acquired at an early age, while social interactions provide key wiring instructions that determine brain development. Human infants need a social environment to survive as they rely on caregivers to maintain allostasis. This Perspective proposes that the need of others to regulate physiological changes determines brain development, not only in the social domain.

Why Interventions to Influence Adolescent Behavior Often Fail but Could Succeed.

Abstract: We provide a developmental perspective on two related issues: (a) why traditional preventative school-based interventions work reasonably well for children but less so for middle adolescents and (b) why some alternative approaches to interventions show promise for middle adolescents. We propose the hypothesis that traditional interventions fail when they do not align with adolescents' enhanced desire to feel respected and be accorded status; however, interventions that do align with this desire can motivate internalized, positive behavior change. We review examples of promising interventions that (a) directly harness the desire for status and respect, (b) provide adolescents with more respectful treatment from adults, or (c) lessen the negative influence of threats to status and respect. These examples are in the domains of unhealthy snacking, middle school discipline, and high school aggression. Discussion centers on implications for basic developmental science and for improvements to youth policy and practice.

Bioinspired Stimuli-Responsive Color-Changing Systems.

Abstract: Stimuli-responsive colors are a unique characteristic of certain animals, evolved as either a method to hide from enemies and prey or to communicate their presence to rivals or mates. From a material science perspective, the solutions developed by Mother Nature to achieve these effects are a source of inspiration to scientists for decades. Here, an updated overview of the literature on bioinspired stimuli-responsive color-changing systems is provided. Starting from natural systems, which are the source of inspiration, a classification of the different solutions proposed is given, based on the stimuli used to trigger the color-changing effect.

Toward a Consensus on the Definition and Taxonomy of Power System Resilience

Abstract: This paper analyzes the notion of resilience in power systems from a fundamental viewpoint and thoroughly examines its practical implications. This paper aims to describe and classify different high-impact rare (HR) events, provide a more technical definition of power system resilience, and discuss linkages between resilience and other well-established concepts, such as security and reliability. Most relevant decisions of system operators in the face of HR events involve a significant level of stress and strain. In order to make informed decisions within this context, it is crucial to have an all-inclusive picture of the state of the system. This paper provides an appropriate framework that not only characterizes the various states of the system but also derives informed decisions from a resilience-oriented perspective. It also describes and analyzes diverse resilience improvement strategies. Comprehensive models and classifications are provided to clearly capture various aspects of power system resilience.

Strategic Flexibility: A Review of the Literature

Abstract: Previous literature reviews of strategic flexibility have a number of shortcomings: they lack a specific focus in the field, provide an excessive definitional focus or lack a clear empirical overview of research in the field. To overcome these shortcomings, this paper aims to systematically analyse the literature on strategic flexibility by identifying its main characteristics, linking the different aspects together in a new conceptual framework, and considering the means to measure it. This comprehensive analytical model analyses various aspects of strategic flexibility in the relevant literature (156 contributions). Thus, the systematic and critical approach of this paper offers a novel perspective in understanding strategic flexibility, and contributes to the field by providing a consolidation of the literature and indicating future research avenues.

The power of semiotic software: a critical multimodal perspective

Abstract: Digital technologies play a fundamental role in facilitating and disseminating promotional discourse in ever more domains of public and private life, as software "structures and makes possible much of the contemporary world". Semiotic software – in contrast to earlier technologies such as the pen or the typewriter – enables users to select from a range of different semiotic resources, and incorporates and represents knowledge about what constitutes effective use of these resources in particular contexts. This chapter argues that to understand the power of semiotic software people need to adopt a holistic perspective, one that is multimodal and critical, and pays attention to the interaction between software design and use and its relation to broader semiotic and social practices. It focuses on the power of software to intervene in the ways people use language and other semiotic resources. This power rests, first of all, on the ever increasing necessity to use software in all spheres of post-industrial life.

Social Comparison as the Thief of Joy: Emotional Consequences of Viewing Strangers’ Instagram Posts

Abstract: This experiment investigates the emotional consequences of viewing strangers’ positive posts on Instagram. From a social comparison perspective, strangers’ positive posts on social media are expect...

The ability of societies to adapt to twenty-first-century sea-level rise

Abstract: Against the background of potentially substantial sea-level rise, one important question is to what extent are coastal societies able to adapt? This question is often answered in the negative by referring to sinking islands and submerged megacities. Although these risks are real, the picture is incomplete because it lacks consideration of adaptation. This Perspective explores societies’ abilities to adapt to twenty-first-century sea-level rise by integrating perspectives from coastal engineering, economics, finance and social sciences, and provides a comparative analysis of a set of cases that vary in terms of technological limits, economic and financial barriers to adaptation and social conflicts.

Cardiovascular disease: The rise of the genetic risk score.

Abstract: In a Perspective, Joshua Knowles and Euan Ashley discuss the potential for use of genetic risk scores in clinical practice

Generalized trust narrows the gap between environmental concern and pro-environmental behavior: Multilevel evidence

Abstract: Research has established that people’s environmental concern does not always translate into pro-environmental behavior. On the basis of the social dilemma perspective, the present article examines how this concern-behavior gap can be narrowed. We posit that individuals who are concerned about environmental problems feel reluctant to contribute because they fear being exploited by free riders. We further argue that generalized trust can temper this fear because it allows people to expect others to contribute. Accordingly, we hypothesize that the concern-behavior association is stronger among individuals and societies with higher levels of trust. Findings from multilevel analyses on two international survey datasets (World Values Survey and International Social Survey Programme) support our hypothesis. These findings not only elucidate the concern-behavior gap but also suggest how environmental campaigns can be improved. They also signify the need to explore cross-national variations in phenomena pertaining to environmental concern and behavior.

Explaining Extreme Events of 2016 from a Climate Perspective

Abstract: Editors note: For easy download the posted pdf of the Explaining Extreme Events of 2016 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be ...

Future of Rare Diseases Research 2017–2027: An IRDiRC Perspective

Abstract: Christopher P. Austin1,∗, Christine M. Cutillo1, Lilian P.L. Lau2, Anneliene H. Jonker2, Ana Rath2,3, Daria Julkowska4, David Thomson5, Sharon F. Terry6, Béatrice de Montleau7, Diego Ardigò8, Virginie Hivert7, Kym M. Boycott9, Gareth Baynam10,11, Petra Kaufmann1, Domenica Taruscio12, Hanns Lochmüller13, Makoto Suematsu14, Carlo Incerti15, Ruxandra Draghia-Akli16,17, Irene Norstedt16, Lu Wang18 and Hugh J.S. Dawkins19 on behalf of the International Rare Diseases Research Consortium (IRDiRC)

An affordance perspective of enterprise social media and organizational socialization

Abstract: In response to the challenge of socializing new IT employees, some IT departments are exploring the incorporation of enterprise social media (hereinafter ESM) as an informal organizational socialization tool. Because this is a relatively new phenomenon, little is known about how ESM facilitate employee socialization. In order to contribute to our understanding of how ESM affects employee socialization, this paper invokes a case study to explore how one organization’s implementation of an ESM for its IT new hire program influenced the socialization process and outcomes. To delve deeply into how the ESM influences socialization, we draw upon technology affordance theory to uncover the various first and second-order affordances actualized by different actor groups and the various outcomes resulting from the affordances. We then identify five generative mechanisms – bureaucracy circumvention, executive perspective, personal development, name recognition, and morale booster – that explain how the actualization of different strands of affordances by various groups of users produces eight different outcomes. Our results provide insights into the different affordances made possible by ESM in the context of a new hire socialization program and how these affordances have repercussions beyond those experienced by the individuals using the ESM. The results have important implications for new hire socialization and technology affordance research.

Generalized Unsafety Theory of Stress: Unsafe Environments and Conditions, and the Default Stress Response.

Abstract: Prolonged physiological stress responses form an important risk factor for disease. According to neurobiological and evolution-theoretical insights the stress response is a default response that is always “on” but inhibited by the prefrontal cortex when safety is perceived. Based on these insights the Generalized Unsafety Theory of Stress (GUTS) states that prolonged stress responses are due to generalized and largely unconsciously perceived unsafety rather than stressors. This novel perspective necessitates a reconstruction of current stress theory, which we address in this paper. We discuss a variety of very common situations without stressors but with prolonged stress responses, that are not, or not likely to be caused by stressors, including loneliness, low social status, adult life after prenatal or early life adversity, lack of a natural environment, and less fit bodily states such as obesity or fatigue. We argue that in these situations the default stress response may be chronically disinhibited due to unconsciously perceived generalized unsafety. Also, in chronic stress situations such as work stress, the prolonged stress response may be mainly caused by perceived unsafety in stressor-free contexts. Thus, GUTS identifies and explains far more stress-related physiological activity that is responsible for disease and mortality than current stress theories.

Sedentary Behaviors in Today's Youth: Approaches to the Prevention and Management of Childhood Obesity: A Scientific Statement From the American Heart Association

Abstract: This scientific statement is about sedentary behavior and its relationship to obesity and other cardiometabolic outcomes in youth. A deleterious effect of sedentary behavior on cardiometabolic health is most notable for screen-based behaviors and adiposity; however, this relation is less apparent for other cardiometabolic outcomes or when sedentary time is measured with objective movement counters or position monitors. Increasing trends of screen time are concerning; the portability of screen-based devices and abundant access to unlimited programming and online content may be leading to new patterns of consumption that are exposing youth to multiple pathways harmful to cardiometabolic health. This American Heart Association scientific statement provides an updated perspective on sedentary behaviors specific to modern youth and their impact on cardiometabolic health and obesity. As we reflect on implications for practice, research, and policy, what emerges is the importance of understanding the context in which sedentary behaviors occur. There is also a need to capture the nature of sedentary behavior more accurately, both quantitatively and qualitatively, especially with respect to recreational screen-based devices. Further evidence is required to better inform public health interventions and to establish detailed quantitative guidelines on specific sedentary behaviors in youth. In the meantime, we suggest that televisions and other recreational screen-based devices be removed from bedrooms and absent during meal times. Daily device-free social interactions and outdoor play should be encouraged. In addition, parents/guardians should be supported to devise and enforce appropriate screen time regulations and to model healthy screen-based behaviors.