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Showing papers on "Shear stress published in 2004"


Journal ArticleDOI
TL;DR: It is concluded that, while the Newtonian model of blood viscosity is a good approximation in regions of mid-range to high shear, it is advisable to use the Generalised Power Law model in order to achieve better approximation of wall shear stress at low shear.

627 citations


Journal ArticleDOI
TL;DR: In this paper, a series of ring shear tests was conducted to investigate the development of particle breakage with shear strain for a carbonate sand, and it was found that at very large displacements the soil reached a stable grading, but that the final grading was dependent on both the applied normal stress and the initial grading.
Abstract: A series of ring shear tests was conducted to investigate the development of particle breakage with shear strain for a carbonate sand. It was found that at very large displacements the soil reached a stable grading, but that the final grading was dependent on both the applied normal stress and the initial grading. The particle breakage caused a volumetric compression, which again ceased only when the stable grading had been attained, emphasising that critical states as observed at much smaller strains in triaxial tests are not rigorously defined. Despite the severe degradation of the soil particles the mobilised angle of shearing resistance was found not to change significantly.

524 citations


Journal ArticleDOI
TL;DR: In this paper, the application of the effective stress principle to unsaturated soils is critically reviewed, and the reasons underlying the difficulties in previous investigations of effective stress in unsaturated soil are highlighted.
Abstract: The application of the effective stress principle to unsaturated soils is critically reviewed, and the reasons underlying the difficulties in previous investigations of the effective stress in unsaturated soils are highlighted. The validity of the relationship proposed by Khalili and Khabbaz in 1998 for the determination of the effective stress parameter, χ, is examined using an extensive array of experimental data. It is shown that quantitative predictions of shear strength and volume change in unsaturated soils can be made using the effective stress concept. The uniqueness of the critical state line in the deviatoric stress–effective mean stress plane for saturated as well as unsaturated soils is investigated, and the incremental form of the effective stress parameter is derived.

435 citations


Journal ArticleDOI
TL;DR: A novel technique to assess the relation between fluid dynamic variables and the permeability of the endothelium to macromolecules indicates that in vivo endothelial permeability to albumin decreases with increasing time-average shear stress over the normal range.
Abstract: A better understanding of how hemodynamic factors affect the integrity and function of the vascular endothelium is necessary to appreciate more fully how atherosclerosis is initiated and promoted. A novel technique is presented to assess the relation between fluid dynamic variables and the permeability of the endothelium to macromolecules. Fully anesthetized, domestic swine were intravenously injected with the albumin marker Evans blue dye, which was allowed to circulate for 90 min. After the animals were euthanized, silicone casts were made of the abdominal aorta and its iliac branches. Pulsatile flow calculations were subsequently made in computational regions derived from the casts. The distribution of the calculated time-dependent wall shear stress in the external iliac branches was directly compared on a point-by-point basis with the spatially varying in vivo uptake of Evans blue dye in the same arteries. The results indicate that in vivo endothelial permeability to albumin decreases with increasing time-average shear stress over the normal range. Additionally, endothelial permeability increases slightly with oscillatory shear index.

409 citations


Journal ArticleDOI
TL;DR: A method is presented to solve for shear elasticity and viscosity of a homogeneous medium by measuring shear wave speed dispersion by fitting the theoretical model to solve the complex stiffness of the medium.
Abstract: The propagation speed of shear waves is related to frequency and the complex stiffness (shear elasticity and viscosity) of the medium. A method is presented to solve for shear elasticity and viscosity of a homogeneous medium by measuring shear wave speed dispersion. Harmonic radiation force, introduced by modulating the energy density of incident ultrasound, is used to generate cylindrical shear waves of various frequencies in a homogeneous medium. The speed of shear waves is measured from phase shift detected over the distance propagated. Measurements of shear wave speed at multiple frequencies are fit with the theoretical model to solve for the complex stiffness of the medium. Experiments in gelatin phantoms show promising results validated by an independent method. Practical considerations and challenges in possible medical applications are discussed.

387 citations


Journal ArticleDOI
TL;DR: In this article, the authors analyzed the stress-strain responses of 22 simple metals and ceramics to determine the maximum shear strain a homogeneous crystal can withstand, a property for which they suggest the name shearability.
Abstract: Using density functional theory we analyze the stress-strain responses of 22 simple metals and ceramics to determine the maximum shear strain a homogeneous crystal can withstand, a property for which we suggest the name shearability. A shearability gap is found between metals and covalent ceramics. Shearability of metals further correlates with the degree of valence charge localization and directional bonding. Depending on the deformation constraints, ionic solids may possess even larger shearability than covalent solids. The Frenkel model of ideal shear strength works well for both metals and ceramics when shearability is used in the scaling.

319 citations


Journal ArticleDOI
TL;DR: In this paper, the authors compared shear stress estimated from the log profile, drag, Reynolds and turbulent kinetic energy (TKE) approaches in a simple boundary layer, over plexiglas and over sand, and in a complex flow field around deflectors.
Abstract: Bed shear stress is a fundamental variable in river studies to link flow conditions to sediment transport. It is, however, difficult to estimate this variable accurately, particularly in complex flow fields. This study compares shear stress estimated from the log profile, drag, Reynolds and turbulent kinetic energy (TKE) approaches in a laboratory flume in a simple boundary layer, over plexiglas and over sand, and in a complex flow field around deflectors. Results show that in a simple boundary layer, the log profile estimate is always the highest. Over plexiglas, the TKE estimate was the second largest with a value 30 per cent less than the log estimate. However, over sand, the TKE estimate did not show the expected increase in shear stress. In a simple boundary layer, the Reynolds shear stress seems the most appropriate method, particularly the extrapolated value at the bed obtained from a turbulent profile. In a complex flow field around deflectors, the TKE method provided the best estimate of shear stress as it is not affected by local streamline variations and it takes into account the increased streamwise turbulent fluctuations close to the deflectors. It is suggested that when single-point measurements are used to estimate shear stress, the instrument should be positioned close to 0·1 of the flow depth, which corresponds to the peak value height in profiles of Reynolds and TKE shear stress. Copyright © 2004 John Wiley & Sons, Ltd.

292 citations


Journal ArticleDOI
TL;DR: On monomannose‐coated surfaces, bacteria displayed a complex ‘stick‐and‐roll’ adhesion in which they tended to roll over the surface at low shear but increasingly halted to stick firmly as the shear was increased.
Abstract: It is generally assumed that bacteria are washed off surfaces as fluid flow increases because they adhere through 'slip-bonds' that weaken under mechanical force. However, we show here that the opposite is true for Escherichia coli attachment to monomannose-coated surfaces via the type 1 fimbrial adhesive subunit, FimH. Raising the shear stress (within the physiologically relevant range) increased accumulation of type 1 fimbriated bacteria on monomannose surfaces by up to two orders of magnitude, and reducing the shear stress caused them to detach. In contrast, bacterial binding to anti-FimH antibody-coated surfaces showed essentially the opposite behaviour, detaching when the shear stress was increased. These results can be explained if FimH is force-activated; that is, that FimH mediates 'catch-bonds' with mannose that are strengthened by tensile mechanical force. As a result, on monomannose-coated surfaces, bacteria displayed a complex 'stick-and-roll' adhesion in which they tended to roll over the surface at low shear but increasingly halted to stick firmly as the shear was increased. Mutations in FimH that were predicted earlier to increase or decrease force-induced conformational changes in FimH were furthermore shown here to increase or decrease the probability that bacteria exhibited the stationary versus the rolling mode of adhesion. This 'stick-and-roll' adhesion could allow type 1 fimbriated bacteria to move along mannosylated surfaces under relatively low flow conditions and to accumulate preferentially in high shear regions.

260 citations


Journal ArticleDOI
TL;DR: In this article, the hydrodynamic and thermal fields of a water-γAl2O3 nanofluid in a radial laminar flow cooling system were considered, and it was shown that considerable heat transfer enhancement is possible, even achieving a twofold increase in the case of a 10% nanoparticle volume fraction.

259 citations


Journal ArticleDOI
TL;DR: Overall, accumulation and retention of targeted ultrasound contrast agents is possible under physiologic flow conditions and is strongly influenced by shear stress and surface density of the target receptor.

242 citations


Journal ArticleDOI
TL;DR: It is suggested that catch bonds contribute to the shear threshold for rolling and are a common characteristic of selectin-ligand interactions.

Journal ArticleDOI
TL;DR: In this paper, the authors used ANNs to predict the ultimate shear strength of reinforced concrete (RC) beams with transverse reinforcements, and the results showed that ANNs have strong potential as a feasible tool for predicting the ultimate strength of RC beams with reinforced reinforcement within the range of input parameters considered.

Journal ArticleDOI
TL;DR: The glassy alloy rods exhibit ultra-high fracture strength of 5185 MPa, high Young's modulus of 268 GPa and high specific strength of 6.5B31.

Journal ArticleDOI
TL;DR: The microviscometric method provides a comprehensive quantitative analysis of microvascular hemodynamics that has applications in broad areas of medicine and physiology and is particularly relevant to quantitative studies of angiogenesis, tumor growth, leukocyte adhesion, vascular-flow resistance, tissue perfusion, and endothelial-cell mechanotransduction.
Abstract: We show that many salient hemodynamic flow properties, which have been difficult or impossible to assess in microvessels in vivo, can be estimated by using microviscometry and fluorescent microparticle image velocimetry in microvessels >20 μm in diameter Radial distributions in blood viscosity, shear stress, and shear rate are obtained and used to predict axial pressure gradient, apparent viscosity, and endothelial-cell surface-layer thickness in vivo Based solely on microparticle image velocimetry data, which are readily obtainable during the course of most intravital microscopy protocols from systemically injected particle tracers, we show that the microviscometric method consistently predicted a reduction in local and apparent blood viscosity after isovolemic hemodilution Among its clinical applications, hemodilution is a procedure that is used to treat various pathologies that require reduction in peripheral vascular-flow resistance Our results are directly relevant in this context because they suggest that the fractional decrease in systemic hematocrit is ≈25–35% greater than the accompanying fractional decrease in microvascular-flow resistance in vivo In terms of its fundamental usefulness, the microviscometric method provides a comprehensive quantitative analysis of microvascular hemodynamics that has applications in broad areas of medicine and physiology and is particularly relevant to quantitative studies of angiogenesis, tumor growth, leukocyte adhesion, vascular-flow resistance, tissue perfusion, and endothelial-cell mechanotransduction

Journal ArticleDOI
TL;DR: In this article, direct numerical simulation of a fully developed turbulent channel flow was carried out at three Reynolds numbers, 180, 395, and 640, based on the friction velocity and the channel half width, in order to investigate very large-scale structures and their effects on the wall shear-stress fluctuations.
Abstract: Direct numerical simulation of a fully developed turbulent channel flow has been carried out at three Reynolds numbers, 180, 395, and 640, based on the friction velocity and the channel half width, in order to investigate very large-scale structures and their effects on the wall shear-stress fluctuations

Journal ArticleDOI
TL;DR: The shear viscosity of a two-dimensional liquid-state dusty plasma was measured experimentally; it was of order 1 mm(2) s(-1), depending on the monolayer's parameters and shear stress applied.
Abstract: The shear viscosity of a two-dimensional liquid-state dusty plasma was measured experimentally. A monolayer of highly charged polymer microspheres, with a Yukawa interaction, was suspended in a plasma sheath. Two counterpropagating Ar+ laser beams pushed the particles, causing shear-induced melting of the monolayer and a shear flow in a planar Couette configuration. By fitting the particle velocity profiles in the shear flow to a Navier-Stokes model, the kinematic viscosity was calculated; it was of order 1 mm(2) s(-1), depending on the monolayer's parameters and shear stress applied.

Journal ArticleDOI
TL;DR: The elementary process of a flowing elasto-plastic materials, a plastic event, is focused on, and the long-range perturbation it elastically induces in a medium submitted to a global shear strain is computed.
Abstract: With the eventual aim of describing flowing elasto-plastic materials, we focus here on the elementary process of such a flow, a plastic event, and compute the long-range perturbation it elastically induces in a medium submitted to a global shear strain. We characterize the effect of a nearby wall on this perturbation, and quantify the importance of finite-size effects. Although most of our explicit formulae refer to 2D situations, our statements hold for 3D situations as well.

Proceedings ArticleDOI
TL;DR: The findings revealed that no significant difference occured between the linear viscoelastic behavior of the porcine and the human brain tissue and a visco-hyperelastic model was proposed using the generalized Maxwell model and the Ogden hyperelastic models.
Abstract: This research aims at improving the definition of the shear linear material properties of brain tissue. A comparison between human and porcine white and gray matter samples was carried out over a new large frequency range associated with both traffic road and non-penetrating ballistic impacts. Oscillatory experiments were performed by using an original custom-designed oscillatory shear testing device. The findings revealed that no significant difference occured between the linear viscoelastic behavior of the porcine and the human brain tissue. On the average, the storage modulus (G') and the loss modulus (G") of the white matter increased respectively from 2.1 +/- 0.9 kPa to 16.8 +/- 2.0 kPa and from 0.4 +/- 0.2 kPa to 18.7 +/- 2.3 kPa between 0.1 and 6300 Hz at 37 degrees C. In addition, the gray and white matter behaviors seemed to be similar at small strains. The reliability of the data and the robustness of the experimental protocol were checked using a standard rheometer (Bohlin C-VOR 150). A good agreement was found between the data obtained in the frequency and time field. As a result, the linear relaxation modulus was determined over an extensive time range (from 10(-5) s to 300 s). In a first approach, the nonlinear behavior of brain tissue was studied using stress relaxation tests. Brain tissue showed significant shear softening for strains above 1% and the time relaxation behavior was independent of the applied strain. On this basis, a visco-hyperelastic model was proposed using the generalized Maxwell model and the Ogden hyperelastic model. These models respectively describe the linear relaxation modulus and the strain dependence of the shear stress.

Journal ArticleDOI
TL;DR: bench studies demonstrated that, at the same wall shear stress in a capillary tube, the level of hemolysis was significantly greater for turbulent flow as compared with laminar flow, confirming that turbulent stresses contribute strongly to blood mechanical trauma.
Abstract: Experimental and computational studies were performed to elucidate the role of turbulent stresses in mechanical blood damage (hemolysis). A suspension of bovine red blood cells (RBC) was driven through a closed circulating loop by a centrifugal pump. A small capillary tube (inner diameter 1 mm and length 70 mm) was incorporated into the circulating loop via tapered connectors. The suspension of RBCs was diluted with saline to achieve an asymptotic apparent viscosity of 2.0 +/- 0.1 cP at 23 degrees C to produce turbulent flow at nominal flow rate and pressure. To study laminar flow at the identical wall shear stresses in the same capillary tube, the apparent viscosity of the RBC suspension was increased to 6.3 +/- 0.1 cP (at 23 degrees C) by addition of Dextran-40. Using various combinations of driving pressure and Dextran mediated adjustments in dynamic viscosity Reynolds numbers ranging from 300-5,000 were generated, and rates of hemolysis were measured. Pilot studies were performed to verify that the suspension media did not affect mechanical fragility of the RBCs. The results of these bench studies demonstrated that, at the same wall shear stress in a capillary tube, the level of hemolysis was significantly greater (p < 0.05) for turbulent flow as compared with laminar flow. This confirmed that turbulent stresses contribute strongly to blood mechanical trauma. Numerical predictions of hemolysis obtained by computational fluid dynamic modeling were in good agreement with these experimental data.

Journal ArticleDOI
TL;DR: It is concluded that the fluid shear stress rate is an important parameter for bone cell activation.

Journal ArticleDOI
TL;DR: Results of this study support the view that the non-planarity of blood vessels and thenon-Newtonian properties of blood are an important factor in hemodynamics and may play a significant role in vascular biology and pathophysiology.

Journal ArticleDOI
TL;DR: In this paper, the problem of axial shear of a circular cylindrical tube subject to a radial magnetic field was formulated and then solved for a specific constitutive law with a magnetic field that is initially radial.
Abstract: Magneto-sensitive (MS) elastomers are “smart materials” whose mechanical properties may be changed rapidly by the application of a magnetic field Such materials typically consist of micron-sized ferrous particles dispersed within an elastomeric matrix The equations governing deformations of these materials were discussed in a recent paper by the present authors and applied in a particular specialization of the constitutive model to the problem of axial shear of a circular cylindrical tube subject to a radial magnetic field In the present paper we develop the governing equations for a more general form of constitutive model and provide alternative forms of the equations, including a Lagrangian formulation To illustrate the theory the problem of azimuthal shear of a circular cylindrical tube is formulated and then solved for a specific constitutive law with a magnetic field that is initially radial The results, which show the stiffening of the azimuthal shear stress/strain response with increasing magnetic field strength, are illustrated graphically

Journal ArticleDOI
TL;DR: Findings indicate that stress fiber assembly and realignment provide a novel mode by which cell morphology is altered by mechanical signals.
Abstract: Fluid shear stress greatly influences the biology of vascular endothelial cells and the pathogenesis of atherosclerosis. Endothelial cells undergo profound shape change and reorientation in response to physiological levels of fluid shear stress. These morphological changes influence cell function; however, the processes that produce them are poorly understood. We have examined how actin assembly is related to shear-induced endothelial cell shape change. To do so, we imposed physiological levels of shear stress on cultured endothelium for up to 96 hours and then permeabilized the cells and exposed them briefly to fluorescently labeled monomeric actin at various time points to assess actin assembly. Alternatively, monomeric actin was microinjected into cells to allow continuous monitoring of actin distribution. Actin assembly occurred primarily at the ends of stress fibers, which simultaneously reoriented to the shear axis, frequently fused with neighboring stress fibers, and ultimately drove the poles of the cells in the upstream and/or downstream directions. Actin polymerization occurred where stress fibers inserted into focal adhesion complexes, but usually only at one end of the stress fiber. Neither the upstream nor downstream focal adhesion complex was preferred. Changes in actin organization were accompanied by translocation and remodeling of cell-substrate adhesion complexes and transient formation of punctate cell-cell adherens junctions. These findings indicate that stress fiber assembly and realignment provide a novel mode by which cell morphology is altered by mechanical signals.

Journal ArticleDOI
TL;DR: In this article, a computational analysis of the accuracy of different approximations to the Stokes equations for momentum balance used in ice sheet modeling is performed by solving a particular tractable form of the equations appropriate for small perturbations of the ice surface, describing the uniform flow of ice with a Glen rheology on an infinitely long and broad section.
Abstract: A computational analysis of the accuracy of different approximations to the Stokes equations for momentum balance used in ice sheet modeling is performed by solving a particular tractable form of the equations appropriate for small perturbations of the ice surface, describing the uniform flow of ice with a Glen rheology on an infinitely long and broad section. The approximants comprise the shallow ice approximation and various schemes for incorporating longitudinal stresses and, in one case, the horizontal gradient of the horizontal plane shear stresses. The simplifications lead to a vertically one-dimensional numerical problem, whose solution can be computed rapidly. The relaxation rate of perturbations as well as other response descriptors for the stable full system and approximants are compared. Compared with the shallow ice approximation, the inclusion of longitudinal stresses increases accuracy at shorter wavelengths, but accuracy is poor at wavelengths around or less than the ice sheet thickness. Even though analysis shows that the horizontal gradients of the horizontal plane shear stresses are of similar magnitude to longitudinal stress effects, computations show, in agreement with glaciological belief, that longitudinal stress effects are more significant and need to be corrected for first in practice. Two schemes, a multilayer scheme and a one-layer scheme, are particularly good and should be investigated further in cases where perturbations from uniformity are large. Some other apparently plausible approximations introduce nonphysical instabilities. New schemes need to be assessed in the way described in this paper before being used in real ice sheet models.

Journal ArticleDOI
TL;DR: In this article, the authors estimated the spatio-temporal slip distribution of the 2003 Tokachi-oki, Japan, earthquake from teleseismic body wave and strong ground motion data, and determined the optimal weights of constraints using an optimized Akaike's Bayesian Information Criterion.
Abstract: The spatio-temporal slip distribution of the 2003 Tokachi-oki, Japan, earthquake was estimated from teleseismic body wave and strong ground motion data. To perform stable inversion, we applied smoothing constraints to the slip distribution with respect to time and space, and determined the optimal weights of constraints using an optimized Akaike’s Bayesian Information Criterion (ABIC). We found that the rupture propagates mainly along the dip direction, and the length of the rupture area is shorter than its width. The mean rise time in the shallow asperity is significantly longer than that in the deep asperity, which might be attributed to variable frictional properties or lower strength of the plate interface at shallower depths. The average rupture velocity of deep asperity extends to the shear-wave velocity. The derived source parameters are as follows: seismic moment Mo = 1.7×1021 Nm (Mw 8.0); source duration = 50 sec. We also estimated the shear stress change due to the mainshock on and around the major fault zone. It appears that many aftershocks on the plate boundary took place in and adjacent to the zones of stress increase due to the rupture of the mainshock.

Journal ArticleDOI
TL;DR: In this paper, the response of stream invertebrates to near-bed hydraulic parameters has been studied in a Mediterranean River along a spatial gradient of increasing shear stress in two seasons (spring and autumn) with different hydrological conditions.
Abstract: Summary 1. We relate invertebrate assemblages to direct measurements of near-bed hydraulic conditions that integrate the complex three-dimensional structure of flow close to the bottom. 2. We sampled invertebrate taxa from a Mediterranean River along a spatial gradient of increasing shear stress in two seasons (spring and autumn) with different hydrological conditions. We used a recently described ordination technique, Outlying Mean Index (OMI) analysis, to study the response of stream invertebrates to near-bed hydraulic parameters. 3. The distribution of nearly 70% of the taxa collected was significantly related to the hydraulic parameters assessed. In both seasons, shear stress and Froude number were the most important hydraulic parameters whereas substratum particle size and bed roughness had less influence. Most of the 31 taxa collected in both seasons had a higher OMI (an index showing the deviation between the mean environmental conditions used by a taxon and the mean environmental conditions used by a theoretical taxon uniformly distributed across the studied gradient) in autumn (when flow was greater) and were found in samples with high shear stress and high Froude number. This suggests that benthic invertebrates changed their preferences according to flow conditions. 4. Taxon richness declined with increased shear stress during lower flow in spring. Finally, and agreeing with previous results, the proportion of filter feeders and collector-gatherers was inversely related to shear stress. 5. Our results are a first step towards better habitat suitability models that could inform management decisions.

Journal ArticleDOI
TL;DR: An elastic instability associated with flow-induced clustering in semidilute non-Brownian colloidal nanotubes is reported, with the underlying instability being somewhat ubiquitous in complex fluids.
Abstract: We report an elastic instability associated with flow-induced clustering in semidilute non-Brownian colloidal nanotubes. Rheo-optical measurements are compared with simulations of mechanical flocculation in sheared fiber suspensions, and the evolving structure is characterized as a function of confinement and shear stress. The transient rheology is correlated with the evolution of highly elastic vorticity-aligned aggregates, with the underlying instability being somewhat ubiquitous in complex fluids.

Journal ArticleDOI
TL;DR: In this article, the authors used control method inversions to determine the basal shear stress beneath the Ross ice streams where new high-resolution velocity data sets have recently become available, and the inversion algorithm was adapted from an earlier viscous bed algorithm to allow solution for the basal stress corresponding to a weak plastic bed.
Abstract: [1] We used control method inversions to determine the basal shear stress beneath the Ross ice streams where new high-resolution velocity data sets have recently become available. The inversion algorithm was adapted from an earlier viscous bed algorithm to allow solution for the basal shear stress corresponding to a weak plastic bed. We performed several experiments using synthetic data to determine the quality of the inversions. These experiments indicate that with high-quality surface elevation data (e.g., errors <5 m), the inversions are relatively robust with respect to errors in ice flow velocity and bed topography. The inversions are consistent with seismic and borehole observations and indicate that the Ross ice streams lie atop a bed that is nearly everywhere weak. In contrast, the tributaries feeding these ice streams overlie alternating patches of strong and weak bed.

Journal ArticleDOI
TL;DR: The response of the carotid artery afferent to an AVF varies along the length of the artery, with maximum enlargement, elongation, and tortuosity in the distal segment, just proximal to the AVF.

Journal ArticleDOI
TL;DR: Shear stress enhances the migration speed of endothelial cells by modulating the biophysical force of tractions through the biochemical pathway of Rho-p160ROCK, suggesting that shear Stress enhances both the frontal forward-pulling force and tail retraction.