A
Alain Laederach
Researcher at University of North Carolina at Chapel Hill
Publications - 95
Citations - 4724
Alain Laederach is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 34, co-authored 88 publications receiving 4078 citations. Previous affiliations of Alain Laederach include New York State Department of Health & University of Neuchâtel.
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Journal ArticleDOI
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza,Cyrus P. Zabetian,Cyrus P. Zabetian,Albert Tenesa,Alain Laederach,Jennifer S. Montimurro,Dora Yearout,Dora Yearout,Dora Yearout,Denise M. Kay,Kimberly F. Doheny,Justin Paschall,Elizabeth W. Pugh,Victoria I. Kusel,Randall V. Collura,John W. Roberts,Alida Griffith,Ali Samii,Ali Samii,William K. Scott,John G. Nutt,Stewart A. Factor,Haydeh Payami,Haydeh Payami +23 more
TL;DR: The genome-wide association study of 2,000 individuals with Parkinson's disease and unaffected controls confirmed associations with SNCA and MAPT and detected a new association with the HLA region, which was uniform across all genetic and environmental risk strata and was strong in sporadic and late-onset disease.
Journal ArticleDOI
Toward interoperable bioscience data
Susanna-Assunta Sansone,Philippe Rocca-Serra,Dawn Field,Eamonn Maguire,Chris F. Taylor,Chris F. Taylor,Oliver Hofmann,Hong Fang,Steffen Neumann,Weida Tong,Linda A. Amaral-Zettler,Kimberly Begley,Kimberly Begley,Timothy F. Booth,Lydie Bougueleret,Gully A. P. C. Burns,Brad Chapman,Timothy Clark,Lee-Ann Coleman,Jay Copeland,Sudeshna Das,Antoine de Daruvar,Paula de Matos,Ian Dix,Scott C. Edmunds,Chris T. Evelo,Chris T. Evelo,Mark K. Forster,Pascale Gaudet,Pascale Gaudet,Jack A. Gilbert,Carole Goble,Julian L. Griffin,Julian L. Griffin,Daniel J. Jacob,Daniel J. Jacob,Jos C. S. Kleinjans,Lee Harland,Kenneth Haug,Henning Hermjakob,Shannan J. Ho Sui,Alain Laederach,Shaoguang Liang,Stephen Marshall,Annette McGrath,Emily Merrill,Dorothy Reilly,Magali Roux,Caroline E. Shamu,Catherine A. Shang,Christoph Steinbeck,Anne Trefethen,Bryn Williams-Jones,Katherine Wolstencroft,Ioannis Xenarios,Winston Hide +55 more
TL;DR: The prerequisites for data commoning are described and an established and growing ecosystem of solutions using the shared 'Investigation-Study-Assay' framework to support that vision are presented.
Journal ArticleDOI
Coarse-grained modeling of large RNA molecules with knowledge-based potentials and structural filters
Magdalena A. Jonikas,Randall J. Radmer,Alain Laederach,Rhiju Das,Samuel M. Pearlman,Daniel Herschlag,Russ B. Altman +6 more
TL;DR: A protocol for RNA modeling that uses an RNA-specific knowledge-based potential in a coarse-grained molecular dynamics engine to generate plausible 3D structures, and is used to build in missing loops in the crystal structures of the Azoarcus and Twort ribozymes.
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SAFA: Semi-automated footprinting analysis software for high-throughput quantification of nucleic acid footprinting experiments
TL;DR: SAFA, a semi-automated footprinting analysis software package that achieves accurate gel quantification while reducing the time to analyze a gel from several hours to 15 min or less, and may allow a more comprehensive understanding of molecular interactions.
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Disease-Associated Mutations That Alter the RNA Structural Ensemble
TL;DR: The SNPfold algorithm can help identify RiboSNitches by leveraging GWAS data and an analysis of the mRNA structural ensemble, and it is proposed that the UTR and SNP combinations the authors identify constitute a “RiboSNitch,” that is a regulatory RNA in which a specific SNP has a structural consequence that results in a disease phenotype.