Alan Williams

TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.

TL;DR: A DNA sequencing technology in which scalable, low-cost semiconductor manufacturing techniques are used to make an integrated circuit able to directly perform non-optical DNA sequencing of genomes, showing its robustness and scalability by producing ion chips with up to 10 times as many sensors and sequencing a human genome.

TL;DR: The human genome contains roughly comparable numbers of protein-coding and noncoding genes that are bound by common transcription factors and regulated by common environmental signals.

TL;DR: Validating a large set of Nova RNA targets has led us to identify a multi-tiered network in which Nova regulates the exon content of RNAs encoding proteins that interact in the synapse, which may contribute to tissue-specific functions.

TL;DR: A new exon-centric array is presented that allows genome-wide identification of differential splice variation, and concurrently provides a flexible and inclusive analysis of gene expression, suggesting that the more speculative transcripts, largely based solely on computational prediction, might be novel targets in colon cancer.