Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
- Vol. 5, Iss: 10, pp 1-24
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TLDR
In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.Abstract:
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.read more
Citations
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Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
Darshan B B,Saman Nikeghbalian +1 more
TL;DR: In 2019, the Global Burden of Infectious Diseases, Injuries, and Risk Factors Study (GBD) as discussed by the authors was used to estimate deaths associated with 33 bacterial genera or species across 11 infectious syndromes.
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PLSDB: advancing a comprehensive database of bacterial plasmids.
Georges Pierre Schmartz,Anna Hartung,Pascal Hirsch,Fabian Kern,Tobias Fehlmann,Rolf Müller,Andreas Keller +6 more
TL;DR: The PLSDB database as mentioned in this paper provides a reliable resource for researchers to compare their sequences against selected and annotated previous findings, by visualizing similarity information and allowing for a deeper understanding of custom uploaded sequences.
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Antibiotic Discovery and Resistance: The Chase and the Race
Katia Iskandar,Jayaseelan Murugaiyan,Dalal Hammoudi Halat,Said El Hage,Vindana Chibabhai,Saranya Adukkadukkam,Christine Roques,Laurent Molinier,Pascale Salameh,Maarten M. Van Dongen +9 more
TL;DR: The history and challenges of antibiotics discovery are reviewed and different innovative new leads mechanisms expected to replenish the pipeline are described, while maintaining a promising possibility to shift the chase and the race between the spread of AMR, preserving antibiotic effectiveness, and meeting innovative leads requirements.
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Synthesis and characterization of new functionalized chitosan and its antimicrobial and in-vitro release behavior from topical gel.
Ahmad Edwin Mohamed,Walid E. Elgammal,Ahmed M. Eid,Aya M. Dawaba,Ahmed Ibrahim,Amr H. Fouda,Saber M. Hassan +6 more
TL;DR: In this article , a new chitosan derivative was prepared by linking the chitosa with a novel heterocyclic compound, Benzoimidazolyl-thiadiazole (BzimTD) to form Cs-BzIMTD.
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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections
Bingqing Jia,Xuancheng Du,Weijie Wang,Yu Chao Qu,Xiangdong Liu,Ming-Zhong Zhao,Weifeng Li,Yong-Qiang Li +7 more
TL;DR: NPAS are categorized according to the modes of their physical stimulation, which include mechanical, optical, magnetic, acoustic, and electrical signals, with a focus on their design and antimicrobial mechanisms.
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