Jean-Luc Pernodet

TL;DR: This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.

TL;DR: The data reinforce the idea that exploiting previously unknown or uncultivated microorganisms for the discovery of novel natural products has potential value and suggest a strategy for developing this technology into a realistic and effective drug discovery tool.

TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.

TL;DR: Three antibiotic resistance gene cassettes, derived from the omega interposon, were constructed, carrying different antibiotic resistance genes, conferring resistance to geneticin, hygromycin or viomycin, flanked by short inverted repeats containing transcription and translation termination signals and synthetic polylinkers.

TL;DR: It is demonstrated that AlbC and several other bacterial proteins, presenting moderate similarity to AlbC, also use aminoacyl-tRNAs as substrates to catalyze the formation of the DKP peptide bonds and belong to a newly defined family of enzymes that are named cyclodipeptide synthases (CDPSs).