Alice H. Wang

TL;DR: In this prospective study of older women, cigarette smoking was associated with the MSI-high, CIMP-positive, and BRAF mutation-positive colorectal cancer subtypes, which indicates that epigenetic modification may be functionally involved in smoking-related coloreCTal carcinogenesis.

TL;DR: In this paper, the authors found that ever-smokers were at moderately increased risk for incident colorectal cancer (RR = 1.19, 95% CI = 0.65 to 1.35) compared with neversmokers, and other smoking-related variables (e.g., age at initiation, total duration, average number of cigarettes smoked per day, cumulative pack-years, and induction period) were associated with MSI-high, CIMP-positive, and BRAF mutation-positive tumor subtypes.

TL;DR: The largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls, identified ten independent associated SNPs in nine new loci and found evidence for two additional promising loci below genome-wide significance.

TL;DR: Genetic variation in genes associated with immune response, mitogen-activated protein kinase (MAPK) signaling, lymphocyte trafficking and migration, and coagulation pathways may be important in the etiology of NHL, and should be prioritized in replication studies.

TL;DR: Higher recreational physical activity might reduce the risk of postmenopausal breast cancer overall, and additional mechanisms, besides an effect on body mass, may account for observed protective effects of physical activity in reducing breast cancer.