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Alisa M. Goldstein
Researcher at National Institutes of Health
Publications - 309
Citations - 24663
Alisa M. Goldstein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 72, co-authored 297 publications receiving 22773 citations. Previous affiliations of Alisa M. Goldstein include United States Department of Health and Human Services.
Papers
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Journal ArticleDOI
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Heidi Hahn,Carol Wicking,Peter G. Zaphiropoulos,Mae R. Gailani,Susan Shanley,Abirami Chidambaram,Igor Vorechovsky,Erika Holmberg,Anne Birgitte Undén,Susan Gillies,Kylie Negus,Ian M. Smyth,Carolyn Pressman,David J. Leffell,Bernard Gerrard,Alisa M. Goldstein,Michael Dean,Rune Toftgård,Georgia Chenevix-Trench,Brandon J. Wainwright,Allen E. Bale +20 more
TL;DR: It is proposed that a reduction in expression of the patched gene can lead to the developmental abnormalities observed in the syndrome and that complete loss of patched function contributes to transformation of certain cell types.
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Germline p16 mutations in familial melanoma.
Christopher J. Hussussian,Jeffery P. Struewing,Alisa M. Goldstein,Paul A. T. Higgins,Delphine S. Ally,Michelle D. Sheahan,Wallace H. Clark,Margaret A. Tucker,Nicholas C. Dracopoli +8 more
TL;DR: Nine melanoma-specific mutations were detected in 9p21-linked, but not in 1p36- linked, families, thereby confirming previous reports of genetic heterogeneity and will confirm those causally related to the development of familial melanoma.
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Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Virginia Kimonis,Alisa M. Goldstein,B. Pastakia,Mu Yang,Ronald G. Kase,John J. DiGiovanna,Allen E. Bale,Sherri J. Bale +7 more
TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.
Journal ArticleDOI
Chordoma: incidence and survival patterns in the United States, 1973-1995.
TL;DR: Age-adjusted chordoma incidence rate was age-dependent, more common in males than females, and rare among patients aged <40 years and blacks, and racial disparities in incidence for the two developmental tumors, chordoma and Ewing's sarcoma were revealed.
Journal ArticleDOI
Mutations in SUFU predispose to medulloblastoma
Michael D. Taylor,Ling Liu,Corey Raffel,Chi-chung Hui,Todd G. Mainprize,Xiaoyun Zhang,Ron Agatep,Sharon Chiappa,Luzhang Gao,Anja Lowrance,Aihau Hao,Alisa M. Goldstein,Theodora Stavrou,Stephen W. Scherer,Wieslaw T. Dura,Brandon J. Wainwright,Jeremy A. Squire,James T. Rutka,David Hogg +18 more
TL;DR: It is reported that a subset of children with medulloblastoma carry germline and somatic mutations in SUFU (encoding the human suppressor of fused) of the SHH pathway, accompanied by loss of heterozygosity of the wildtype allele.