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Andrew G. Nicholson

Researcher at National Institutes of Health

Publications -  512
Citations -  87875

Andrew G. Nicholson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Lung cancer & Idiopathic pulmonary fibrosis. The author has an hindex of 113, co-authored 477 publications receiving 73860 citations. Previous affiliations of Andrew G. Nicholson include National Yang-Ming University & University College London.

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The evolution of non-small cell lung cancer metastases in TRACERx

Maise Al Bakir, +277 more
- 12 Apr 2023 - 
TL;DR: In this article , a longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours.
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Blood-based circulating tumor DNA mutations as a diagnostic and prognostic biomarker for lung cancer.

TL;DR: An initial blood‐based circulating tumor DNA (ctDNA) gene signature is developed and the clinical test performance in patients with early primary and secondary lung cancer is validated.
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Morphological and genetic classification of lung cancer: variation in practice and implications for tailored treatment

TL;DR: Tailored therapy of lung cancer requires high‐quality pathology, and pathologists have risen to this challenge, but the nature and degree of variation in practice and quality are unknown.
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Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis.

TL;DR: It was concluded that localization of Hyal and HAS in lung/bronchial pre-neoplastic and neoplastic lesions was inversely related to malignancy, which implied that visualizing these factors could be a useful diagnostic procedure for suspected lung cancer.
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PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD).

TL;DR: There was a significant correlation between PGAM5 expression in cancer tissue and the level of expression of 9 out of 49 previously-defined macrophage transcriptomic signatures with a particular one associated with patient mortality (p < 0.05).