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Aurora Taira
Researcher at University of Helsinki
Publications - 8
Citations - 234
Aurora Taira is an academic researcher from University of Helsinki. The author has contributed to research in topics: Germline mutation & DNA methylation. The author has an hindex of 4, co-authored 6 publications receiving 93 citations.
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Journal ArticleDOI
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans.
Eevi Kaasinen,Outi Kuismin,Outi Kuismin,Kristiina Rajamäki,Heikki Ristolainen,Mervi Aavikko,Johanna Kondelin,Silva Saarinen,Davide G. Berta,Riku Katainen,Elina A. M. Hirvonen,Auli Karhu,Aurora Taira,Tomas Tanskanen,Amjad Alkodsi,Minna Taipale,Ekaterina Morgunova,Kaarle Franssila,Rainer Lehtonen,Markus J. Mäkinen,Kristiina Aittomäki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Mitja I. Kurki,Olli Pietilainen,Morgane Hilpert,Elmo Saarentaus,Jaakko Niinimäki,Jaakko Niinimäki,Juhani Junttila,Kari Kaikkonen,Pia Vahteristo,Radek C. Skoda,Mikko Seppänen,Kari K. Eklund,Jussi Taipale,Jussi Taipale,Outi Kilpivaara,Lauri A. Aaltonen,Lauri A. Aaltonen +40 more
TL;DR: Findings provide insight into the interplay between epigenetic modulators and transcription factor activity in hematological neoplasia, but do not confirm the putative role of TET2 in atherosclerosis.
Journal ArticleDOI
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer
Kristiina Rajamäki,Aurora Taira,Riku Katainen,Niko Välimäki,Anna Kuosmanen,Roosa Maria Plaketti,Toni T. Seppälä,Toni T. Seppälä,Toni T. Seppälä,Maarit Ahtiainen,Erkki Ville Wirta,Emilia Vartiainen,Päivi Sulo,Janne J. Ravantti,Suvi Lehtipuro,Kirsi J. Granberg,Matti Nykter,Tomas Tanskanen,Ari Ristimäki,Selja Koskensalo,Laura Renkonen-Sinisalo,Anna Lepistö,Jan Böhm,Jussi Taipale,Jukka-Pekka Mecklin,Mervi Aavikko,Kimmo Palin,Lauri A. Aaltonen +27 more
TL;DR: In this article, the authors comprehensively characterize IBD-associated tumorigenesis integrating multiple high-throughput approaches, and compare the results with in-house data sets from sCRCs.
Journal ArticleDOI
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival.
Tatiana Cajuso,Päivi Sulo,Tomas Tanskanen,Riku Katainen,Aurora Taira,Ulrika A. Hänninen,Johanna Kondelin,Linda M. Forsström,Niko Välimäki,Mervi Aavikko,Eevi Kaasinen,Ari Ristimäki,Selja Koskensalo,Anna Lepistö,Laura Renkonen-Sinisalo,Toni T. Seppälä,Teijo Kuopio,Jan Böhm,Jukka-Pekka Mecklin,Outi Kilpivaara,Esa Pitkänen,Kimmo Palin,Lauri A. Aaltonen +22 more
TL;DR: It is shown that retrotransposon activity associates with clinical features of the disease, and high number of insertions is independently associated with poor disease-specific survival.
Journal ArticleDOI
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma
Davide G. Berta,Heli Kuisma,Niko Välimäki,Maritta Räisänen,Maija Jäntti,Annukka Pasanen,Auli Karhu,Jaana Kaukomaa,Aurora Taira,Tatiana Cajuso,Sanna Nieminen,Rosa-Maria Penttinen,Saija Ahonen,Rainer Lehtonen,Miika Mehine,Pia Vahteristo,Jyrki Jalkanen,Biswajyoti Sahu,Janne J. Ravantti,Netta Mäkinen,Kristiina Rajamäki,Kimmo Palin,Jussi Taipale,Oskari Heikinheimo,Ralf Bützow,Eevi Kaasinen,Lauri A. Aaltonen +26 more
TL;DR: In this paper, the authors identify mutations in genes encoding six members of the SRCAP histone-loading complex (SRCAP-H2A.Z), which are associated with the development of uterine leiomyomas.
Journal ArticleDOI
Contribution of allelic imbalance to colorectal cancer
Kimmo Palin,Esa Pitkänen,Mikko P. Turunen,Biswajyoti Sahu,Päivi Pihlajamaa,Teemu Kivioja,Eevi Kaasinen,Eevi Kaasinen,Niko Välimäki,Ulrika A. Hänninen,Tatiana Cajuso,Mervi Aavikko,Sari Tuupanen,Outi Kilpivaara,Linda van den Berg,Johanna Kondelin,Tomas Tanskanen,Riku Katainen,Marta Grau,Heli Rauanheimo,Roosa-Maria Plaketti,Aurora Taira,Päivi Sulo,Tuomo Hartonen,Kashyap Dave,Bernhard Schmierer,Sandeep Kumar Botla,Maria Sokolova,Anna Vähärautio,Kornelia Gladysz,Halit Ongen,Emmanouil T. Dermitzakis,Jesper B. Bramsen,Torben F. Ørntoft,Claus L. Andersen,Ari Ristimäki,Ari Ristimäki,Anna Lepistö,Laura Renkonen-Sinisalo,Jukka-Pekka Mecklin,Jussi Taipale,Jussi Taipale,Jussi Taipale,Lauri A. Aaltonen,Lauri A. Aaltonen +44 more
TL;DR: The authors use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis and report loss of TP53 as a driver of AI.